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gene 1,229 words KG: LILRB2
Contents

LILRB2 — Leukocyte Immunoglobulin-Like Receptor B2

🧬 Gene Info
Gene SymbolLILRB2
Full NameLeukocyte Immunoglobulin-Like Receptor B2
Chromosome19q13.42
Protein TypeReceptor
Functionencodes an inhibitory immunoreceptor on chromosome 19q13.
Primary ExpressionMicroglia, Macrophages, Monocytes, Dendritic cells, Osteoclasts
Amino Acids598 aa
Exons16
PathwaysAmyloid, Complement, Phagocytosis, Stem Cell
UniProt IDQ8N423
NCBI Gene ID10288
Ensembl IDENSG00000131042
OMIM604815
GeneCardsLILRB2
Human Protein AtlasLILRB2
Associated DiseasesAlzheimer's Disease, Parkinson's Disease
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections125 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68TREM2-mediated microglial tau clearance enhancement
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_withABI3 Gene
gene · KG edge: associated_withACE Gene
gene · KG edge: associated_withadam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

LILRB2 inhibits TREM2
TREM2 inhibits LILRB2
DAP12 inhibits LILRB2
APOE co_discussed LILRB2
APP co_discussed LILRB2
BIN1 co_discussed LILRB2
CD2AP co_discussed LILRB2
CLU co_discussed LILRB2
CR1 co_discussed LILRB2
CTSB co_discussed LILRB2

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