gene 648 words KG: L1CAM
Contents

L1CAM (L1 Cell Adhesion Molecule)

🧬 Gene Info
Gene SymbolL1CAM
ChromosomeXq28
Protein TypeImmunoglobulin superfamily CAM
Functionis a neural cell adhesion molecule that plays critical roles in neuronal development, axonal guidance, myelination, and synaptic plasticity.
Primary ExpressionCNS (neurons, glia), PNS, developing brain
Amino Acids1400 aa
PathwaysMAPK, PI3K
UniProt IDP32004
NCBI Gene ID3909
GeneCardsL1CAM
Human Protein AtlasL1CAM
Associated Diseasesneurodegeneration
InteractionsAGING, ALZHEIMER, ATG12, AUTOPHAGY, DEMENTIA, LC3
KG Connections57 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (14)

Clusterin (ApoJ) - AD Biomarker
biomarker · KG edge: regulates
Astrocytes
entity · KG edge: therapeutic_target
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: interacts_with
ARID1A
gene · KG edge: expressed_in
ATG12 — Autophagy Related 12
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ARID1A expressed_in L1CAM
PI3K expressed_in L1CAM
POLE treats L1CAM
L1CAM expressed_in AKT
L1CAM expressed_in MTOR
CLUSTERIN regulates L1CAM
ATG12 associated_with L1CAM
L1CAM associated_with LC3
CD63 associated_with L1CAM
CD9 associated_with L1CAM

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