Contents

KAT2A (Lysine Acetyltransferase 2A)

🧬 Gene Info

Gene Symbol	KAT2A
Full Name	Lysine Acetyltransferase 2A
Chromosome	17q21.2
Protein Type	Transferase
Function	encodes a histone acetyltransferase that catalyzes the acetylation of histone H3 at lysines 9, 14, 18, and 36 (H3K9ac, H3K14ac, H3K18ac, H3K36ac).
Amino Acids	837 aa
Pathways	Chaperone, Invasion, Metastasis, Tgf-Β, Tgf-Β Signaling
UniProt ID	[Q92830](https://www.uniprot.org/uniprot/Q92830)
Ensembl ID	ENSG00000108773
GeneCards	KAT2A
Human Protein Atlas	KAT2A
HAT domain	Catalytic acetyltransferase domain that transfers acetyl groups from acetyl-CoA to histone lysine residues
Bromodomain	Chromatin reader module that recognizes pre-existing acetylated histones, particularly H4K16ac, enabling positive-feedback acetylation spreading
ADA2-interaction domain	Mediates incorporation into the SAGA (Spt-Ada-Gcn5-Acetyltransferase) and ATAC (Ada Two A-Containing) multi-subunit complexes
ATAC complex	Contains KAT2A and the histone acetyltransferase ATAC2. ATAC specifically acetylates H3K14 and H4K5/12 at enhancers and is involved in mitotic chromosome condensation.
Associated Diseases	Parkinson, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, AMPK, AND, ATG, CALCOCO2, CANCER
KG Connections	211 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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