| Gene Symbol | IL6 |
| Full Name | Interleukin 6 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Epigenetic |
| Ensembl ID | ENSG00000136244 |
| GeneCards | IL6 |
| Human Protein Atlas | IL6 |
| IL-6R (CD126) | Membrane-bound receptor |
| gp130 (CD130) | Signal-transducing subunit (shared with other IL-6 family cytokines) |
| JAK/STAT3 | Primary signaling pathway |
| MAPK/ERK | Secondary signaling cascade |
| Soluble IL-6R (sIL-6R) | Generated by proteolytic cleavage or alternative splicing |
| Trans-signaling | Enables IL-6 response in cells lacking membrane IL-6R |
| Pro-inflammatory | Trans-signaling is primarily pro-inflammatory |
| Macrophages/Monocytes | Primary source, TLR-stimulated |
| Associated Diseases | AD, Aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | Andrographis paniculata, Anti-IL6 Antibody, DUPILUMAB, IRN, MELATONIN, quercetin |
| Interactions | A2M, ABCB1, ABCG2, ACACA, ACE, ACSL4 |
| KG Connections | 2136 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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