Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CAF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| miR-522 | associated_with | compound | 0.95 |
| miR-522 | expressed_in | biomarker | 0.90 |
| Exosomes | expressed_in | compound | 0.85 |
| chemo-resistance | promotes | phenotype | 0.85 |
| Drug Resistance | contributes_to | phenotype | 0.85 |
| Gastric Cancer | contributes_to | disease | 0.85 |
| Tumor Progression | associated_with | process | 0.85 |
| TUMOR_PROGRESSION | activates | phenotype | 0.72 |
| IL6 | secretes | protein | 0.64 |
| CANCER_CELLS | interacts_with | cell_type | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| G3BP1 NTF2L Domain-Mediated mRNP Scaffold Creates Core Exclu | 0.633 | neurodegeneration | What determines the spatial organization |
| Hierarchical Phase Separation with Scaffold Cores | 0.630 | neurodegeneration | What determines the specificity of RNA-p |
| Activity-dependent MAP6 scaffolding at synapses | 0.600 | neurodegeneration | View |
| Competition with G3BP1-Caprin1/FMRP Scaffold Formation | 0.590 | neurodegeneration | How does TRIM21-mediated K63 ubiquitinat |
| Multivalent Scaffold Theory: Rif1 SAF Domain Array as High-V | 0.583 | molecular biology | What physicochemical properties determin |
| Structured Intronic Scaffold Regions in Enhancer-dilncRNAs E | 0.489 | molecular biology | What are the conserved secondary structu |
| Galectin-3 as Damage-Sensor Scaffold for Multimeric Cross-Se | 0.455 | neurodegeneration | Protein aggregation cross-seeding across |
| Cdk5/p25-PSD-95 Phosphorylation Disrupts Synaptic Scaffoldin | 0.455 | neurodegeneration | Quantitative proteomics of the aging syn |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CAF in their description or question text
Score: 0.489 · molecular biology · 2026-04-21
## Mechanistic Overview Structured Intronic Scaffold Regions in Enhancer-dilncRNAs Enable Cell-Type Selective Targeting
Score: 0.455 · neurodegeneration · 2026-04-27
Galectin-3's carbohydrate recognition domain binds exposed glycans on ruptured endolysosomal membranes while its intrins
Score: 0.455 · neurodegeneration · 2026-04-27
Age-dependent p35-to-p25 cleavage activates Cdk5, which phosphorylates PSD-95 S561, disrupting AMPA/NMDA receptor anchor