| Gene Symbol | MMP12 |
| Full Name | Matrix Metalloproteinase 12 |
| Aliases | Page for MMP12 |
| Chromosome | 11q22.2 |
| Protein Type | Enzyme |
| Function | MMP12 encodes a matrix metalloproteinase with unique substrate specificity and physiological functions. |
| Primary Expression | macrophages and microglia |
| Amino Acids | 470 aa |
| Pathways | Immune Response, Lipid Metabolism |
| Ensembl ID | ENSG00000196612 |
| GeneCards | MMP12 |
| Human Protein Atlas | MMP12 |
| Elastin Degradation | MMP12 is one of the few human enzymes capable of degrading native (cross-linked) elastin, making it essential for tissue remodeling in lungs, blood vessels, and other elastic tissues. [@shapiro2019] |
| Extracellular Matrix Remodeling | Beyond elastin, MMP12 can degrade various matrix components including collagen IV, laminin, and fibronectin. |
| Prodomain Function | The propeptide domain maintains latency; activation requires cleavage by other proteases including plasmin, matrilysin (MMP7), and stromelysin (MMP3). |
| Associated Diseases | Als, Coronary Artery Disease, Inflammation, Stroke |
| Interactions | ACE2, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND |
| KG Connections | 116 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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