gene 1,797 words KG: GDAP1
Contents

GDAP1 — Ganglioside-Induced Differentiation-Associated Protein 1

🧬 Gene Info
Gene SymbolGDAP1
Full NameGanglioside-Induced Differentiation-Associated Protein 1
Chromosome8q21.11
Protein FamilyMitochondrial fission proteins
Functionencodes a mitochondrial outer membrane protein that plays a critical role in regulating mitochondrial dynamics, particularly mitochondrial fission.
Subcellular Localizationthe mitochondrial outer membrane. The protein contains several functional domains:
Molecular Weight41 kDa
Amino Acids401 aa
PathwaysAutophagy, Mitophagy
UniProt IDQ9UPN3
NCBI Gene ID78986
Ensembl IDENSG00000104381
OMIM607706
GeneCardsGDAP1
Human Protein AtlasGDAP1
Associated DiseasesAutosomal Recessive Ataxia, Neuropathy, Peripheral Neuropathy
InteractionsAND, AUTOPHAGY, BCL2, BNIP3, BNIP3L, MITOPHAGY
KG Connections24 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Ganglioside Rebalancing Therapy
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (10)

Neurodegeneration
disease · KG edge: implicated_in
TFEB (Redirect)
redirect · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Genes
index · KG edge: expressed_in
BCL2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

GDAP1 activates TFEB
GDAP1 contributes_to LC3
BCL2 activates GDAP1
BNIP3 activates GDAP1
BNIP3L activates GDAP1
GDAP1 causes Peripheral Neuropathy
GDAP1 causes Autosomal Recessive Ataxia
GDAP1 associated_with MFSD8
GDAP1 associated_with SETX
AFG3L2 associated_with GDAP1

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