gene 585 words KG: GAIN
Contents

GAIN Gene - GABA-A Receptor Associated Protein Like 2

🧬 Gene Info
Gene SymbolGAIN
Full NameGAIN - GABA-A Receptor Associated Protein Like 2
AliasesPage for GAIN Gene, GABARAPL2
Chromosome16p13.3
Protein TypeGene
Functionencodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family.
Primary Expressionvarious tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism
NCBI Gene ID124454
GeneCardsGAIN
Human Protein AtlasGAIN
Associated Diseasesaging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
InteractionsACAT1, ACC, ACHE, Actin, AGING, AIF
KG Connections1870 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (158)

Cross-Seeding Prevention Strategy
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CX43 hemichannel engineering enables size-selective mitochon
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TREM2 Conformational Stabilizers for Synaptic Discrimination
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Pericyte Contractility Reset via Selective PDGFR-β Agonism
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Flotillin-1 Stabilization Compounds
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R-Loop Resolution Enhancement Therapy
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Chaperone-Mediated APOE4 Refolding Enhancement
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Osmotic Gradient Restoration via Selective AQP1 Enhancement
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Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
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...
Score: 0.68
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
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Mitochondrial-Lysosomal Contact Site Engineering
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Lipid Droplet Dynamics as Phenotype Switches
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Complement C1q Subtype Switching
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Related Analyses (30)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (9)

acc-chronic-pain
cell_type · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ABCG1 Gene
gene · KG edge: expressed_in
ADRB2 Gene
gene · KG edge: causes
AIF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TIGAR activates GAIN
IDH2 activates GAIN
GAIN activates TKT
TMEM119 biomarker_for GAIN
P2RY12 biomarker_for GAIN
GAIN biomarker_for TREM2
GAIN inhibits GABRA1
GABRA1 associated_with GAIN
GAIN associated_with DLK1
VCP activates GAIN

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