gene 585 words KG: GAIN
Contents

GAIN Gene - GABA-A Receptor Associated Protein Like 2

🧬 Gene Info
Gene SymbolGAIN
Full NameGAIN - GABA-A Receptor Associated Protein Like 2
AliasesPage for GAIN Gene, GABARAPL2
Chromosome16p13.3
Protein TypeGene
Functionencodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family.
Primary Expressionvarious tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism
NCBI Gene ID124454
GeneCardsGAIN
Human Protein AtlasGAIN
Associated Diseasesaging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
InteractionsACAT1, ACC, ACHE, Actin, AGING, AIF
KG Connections1870 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (158)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
APOE-Dependent Autophagy Restoration
Score: 0.88
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
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Related Analyses (30)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (9)

acc-chronic-pain
cell_type · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ABCG1 Gene
gene · KG edge: expressed_in
ADRB2 Gene
gene · KG edge: causes
AIF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TIGAR activates GAIN
IDH2 activates GAIN
GAIN activates TKT
TMEM119 biomarker_for GAIN
P2RY12 biomarker_for GAIN
GAIN biomarker_for TREM2
GAIN inhibits GABRA1
GABRA1 associated_with GAIN
GAIN associated_with DLK1
VCP activates GAIN

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