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gene 918 words KG: FNDC5
Contents

FNDC5 — Fibronectin Type III Domain Containing 5

🧬 Gene Info
Gene SymbolFNDC5
Full NameFibronectin Type III Domain Containing 5
Chromosome1p36.22
Functionis a gene located on chromosome 1p36.
Primary ExpressionSkeletal muscle (primary), hippocampus, cortex, heart
Amino Acids112 aa
PathwaysDna Repair, Dopamine Pathways, Inflammasome, Mapk, Mitophagy
UniProt IDQ8IZF6
NCBI Gene ID56852
Ensembl IDENSG00000100597
GeneCardsFNDC5
Human Protein AtlasFNDC5
Genomic coordinates~10,000 bp coding region
OrientationPlus strand
IsoformsMultiple splice variants identified
Associated DiseasesAlzheimer, Alzheimer's disease, Ataxia, diabetes
InteractionsAGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AND
KG Connections273 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77Transcriptional Autophagy-Lysosome Coupling
Score: 0.76SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Glycine-Rich Domain Competitive Inhibition
Score: 0.64Low Complexity Domain Cross-Linking Inhibition
Score: 0.62Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61Digital Twin-Guided Metabolic Reprogramming
Score: 0.55Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: inhibitsApoptosis in Neurodegeneration
entity · KG edge: biomarker_forAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_forAstrocytes
entity · KG edge: inhibitsATR Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

FGF21 activates FNDC5
APP biomarker_for FNDC5
FNDC5 biomarker_for S100B
FNDC5 activates PLAU
FNDC5 activates CXCL10
FNDC5 biomarker_for C1Q
FNDC5 activates CX3CL1
FNDC5 activates VIM
FNDC5 activates BDNF
FNDC5 biomarker_for TGM2

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