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gene 2,879 words KG: CD33
Contents

CD33 — Cluster of Differentiation 33

🧬 Gene Info
Gene SymbolCD33
Full NameCluster of Differentiation 33
AliasesSiglec-3
Chromosome19q13.41
FunctionSialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight67 kDa
Amino Acids354 aa
Exons7
PathwaysApoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt ID[P20138](https://www.uniprot.org/uniprot/P20138)
GeneCardsCD33
Human Protein AtlasCD33
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsStem Cell Therapy
InteractionsABCA7, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
SciDEX HypothesesCD33-Dependent Switch Hypothesis: CD33 Antagonism
KG Connections654 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66LRP1-Dependent Tau Uptake Disruption
Score: 0.60VCP-Mediated Autophagy Enhancement
Score: 0.59Extracellular Vesicle Biogenesis Modulation
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
← Prevpg 2/2

Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40

See Also (9)

ABCA7 (Redirect)
redirect · KG edge: activatesABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_withABI3 Gene
gene · KG edge: associated_withACE Gene
gene · KG edge: associated_withADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

TYROBP interacts_with CD33
TYROBP associated_with CD33
APP interacts_with CD33
PSEN1 interacts_with CD33
CD33 interacts_with OVERVIEW
CD33 interacts_with PSEN1
CD33 inhibits BCL2
APP activates CD33
CD33 activates OVERVIEW
CD33 activates PSEN1

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