gene 940 words KG: CALR
Contents

CALR Gene

🧬 Gene Info
Gene SymbolCALR
Full NameCalreticulin
Chromosome19p13.2
FunctionCalreticulin performs several essential cellular functions:
Subcellular Localizationthe endoplasmic reticulum (ER). Calreticulin is essential for calcium homeostasis, protein quality control, and cellular
Molecular Weight48 kDa
Amino Acids417 aa
PathwaysPyroptosis
UniProt ID[P27797](https://www.uniprot.org/uniprot/P27797)
Ensembl IDENSG00000179218
GeneCardsCALR
Human Protein AtlasCALR
Associated DiseasesALS, dementia, frontotemporal, Ms, neurodegeneration, Tumor
InteractionsAND, APAF1, APOPTOSIS, CANCER, CANX, GSDME
KG Connections70 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66

Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
APAF1 Gene
gene · KG edge: inhibits
BCL2 Gene
gene · KG edge: regulates
CANX — Calnexin
gene · KG edge: inhibits
CTSD — Cathepsin D
gene · KG edge: associated_with

Knowledge Graph (12 edges)

WLS interacts_with CALR
BCL2 regulates CALR
CALR activates GSDME
CALR associated_with S100A6
CALR expressed_in AKT
CALR associated_with PRDX5
CALR associated_with CTSD
CALR regulates BCL2
CALR inhibits RIPK1
CALR activates TNFSF10

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.