| Gene Symbol | CACNA1D |
| Chromosome | 3p21.1 |
| Protein Family | Voltage-gated calcium channel (Cav1) family |
| Function | CACNA1D encodes the α1D subunit of voltage-dependent L-type calcium channels, also known as Cav1.3 |
| Primary Expression | neurons, cardiac pacemaker cells, and endocrine cells |
| Subcellular Localization | Cell membrane, dendritic shafts, presynaptic terminals |
| Molecular Weight | 245 kDa |
| UniProt ID | [Q01658](https://www.uniprot.org/uniprot/Q01658) |
| GeneCards | CACNA1D |
| Human Protein Atlas | CACNA1D |
| α1 Subunit (CACNA1D) | Forms the transmembrane pore |
| β Subunit | Auxiliary subunit affecting trafficking and kinetics |
| α2δ Subunit | Auxiliary subunit increasing surface expression |
| γ Subunit | Modulatory subunit (in some tissues) |
| Low-Voltage Activation | Activates at potentials as negative as -50 mV (vs. -30 mV for Cav1.2) |
| Associated Diseases | neurodegeneration |
| Interactions | CACNA1A, CACNA1C, CACNA1E, cacna1f, CACNA1F, CACNA1G |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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