| Gene Symbol | CACNA1F |
| Full Name | Calcium Voltage-Gated Channel Auxiliary Subunit Alpha1F |
| Aliases | Page for CACNA1F Protein |
| Chromosome | Xp11.23 |
| Function | is located on chromosome Xp11.23 and encodes the alpha1F subunit of voltage-gated calcium channels, known as Cav1.4 |
| Primary Expression | retinal photoreceptors (both rods and cones) where it mediates the influx of calcium ions necessary for synaptic vesicle release and proper transmissi |
| Amino Acids | 166 aa |
| UniProt ID | [O43497](https://www.uniprot.org/uniprot/O43497) |
| Ensembl ID | ENSG00000102040 |
| GeneCards | CACNA1F |
| Human Protein Atlas | CACNA1F |
| Low-voltage activation threshold | Cav1.4 activates at more negative membrane potentials compared to other HVA channels |
| Slow deactivation kinetics | The channel remains open longer, supporting sustained calcium influx |
| Interaction with accessory subunits | Specifically associates with beta2 and alpha2delta-4 subunits in retinal cells |
| Rod photoreceptors | Critical for scotopic (low-light) vision |
| Associated Diseases | neurodegeneration research |
| Interactions | CACNA1A, CACNA1C, CACNA1D, CACNA1E, CACNA1G, CACNA1H |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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