gene 2,013 words KG: ATG4B
Contents

ATG4B — Autophagy Related 4B Cysteine Peptidase

🧬 Gene Info
Gene SymbolATG4B
Full NameAutophagy Related 4B Cysteine Peptidase
Chromosome2q37.3
Protein TypeProtease
Functionencodes a cysteine protease that plays a fundamental role in the autophagy pathway, the cell's primary degradation system for clearing damaged proteins, aggregates, and organelles.
Amino Acids393 aa
UniProt IDATG4A
NCBI Gene ID23192
Ensembl IDENSG00000135679
OMIM604353
GeneCardsATG4B
Human Protein AtlasATG4B
Associated DiseasesAls
Known Drugs/CompoundsK33-Branched Ubiquitin Chains
InteractionsALS, AND, APOPTOSIS, App, ATG13, ATG3
KG Connections199 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.85
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Glycine-Rich Domain Competitive Inhibition
Score: 0.64

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ATG13 — Autophagy Related 13
gene · KG edge: contributes_to
ATG3 Gene
gene · KG edge: contributes_to
ATG5 — Autophagy Related 5
gene · KG edge: activates

Knowledge Graph (12 edges)

ATG4B regulates LC3_II
CAT therapeutic_target ATG4B
ATG4B therapeutic_target ATG3
ATG13 contributes_to ATG4B
ATG5 contributes_to ATG4B
BECN1 contributes_to ATG4B
NCOA4 activates ATG4B
ATG7 contributes_to ATG4B
RAB7A activates ATG4B
ATG4B contributes_to ATG3

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