gene 1,764 words KG: ABHD12
Contents

ABHD12 Gene

🧬 Gene Info
Gene SymbolABHD12
Full NameAlpha/Beta Hydrolase Domain Containing 12
Chromosome20p11.21
Protein TypeHydrolase
Functionencodes a brain-enriched serine hydrolase enzyme that plays critical roles in lipid metabolism, endocannabinoid signaling, and neuroimmune function.
Primary Expressionthe central nervous system, particularly in neurons, microglia, and oligodendrocytes, where it hydrolyzes various lipid substrates including monoacylg
Exons14
UniProt IDQ9NWU1
NCBI Gene ID553155
Ensembl IDENSG00000153048
OMIM613599
GeneCardsABHD12
Human Protein AtlasABHD12
Associated DiseasesFreezing Tolerance
InteractionsBRCA1
KG Connections8 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Membrane Cholesterol Gradient Modulators
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
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Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (2)

Neurodegeneration
disease · KG edge: implicated_in
BRCA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (8 edges)

ABHD12 interacts_with BRCA1
ABHD12 interacts_with HOS1
ABHD12 associated_with Freezing Tolerance
ABHD12 participates_in CBF Pathway
ABHD12 member_of R-HSA-426048
genes-abhd12 describes ABHD12
ABHD12 data_in benchmark_ot_ad_answer_key:ABHD12
benchmark_ot_ad_answer_key:ABHD12 data_in ABHD12

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