Clinical experiment designed to assess clinical efficacy targeting N/A in human patients. Primary outcome: prevalence of motoric cognitive risk syndrome
A cross-sectional study examining the association between adverse childhood experiences (ACEs) and motoric cognitive risk syndrome (MCR) among older adults in China. The study investigated whether Depression and chronic pain mediate the relationship between ACEs and MCR. Twelve ACE indicators were assessed across conventional, extended, and new categories. MCR was diagnosed based on cognitive complaints and slow gait speed. The research used data from the China Health and Retirement Longitudinal Study (CHARLS) and employed multiple regression models and parallel mediation analyses to examine the associations. The study found that ACEs showed dose-dependent associations with MCR, with participants having 1-3 ACEs and ≥4 ACEs showing significantly higher odds of developing MCR compared to those without ACEs. Depression and chronic pain were found to partially mediate this relationship.
Cross-sectional analysis using CHARLS data. Assessment of 12 ACE indicators across categories. MCR diagnosis based on cognitive complaints and slow gait speed. Depression evaluation using 10-item Center for Epidemiologic Studies Depression Scale. Chronic pain assessment through standardized questionnaires. Multiple regression models and parallel mediation analyses.
Higher prevalence of MCR in individuals with more ACEs, with depression and chronic pain serving as mediators
Statistically significant associations between ACEs and MCR, demonstration of mediation effects
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