gene 683 words KG: C1QB
Contents

C1QB — Complement Component 1Q Beta

🧬 Gene Info
Gene SymbolC1QB
Full NameComplement Component 1Q Subunit Beta
Chromosome1p36.12.
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe liver as the main source of circulating C1q
Amino Acids245 aa
Exons2
PathwaysComplement, Immune Response
NCBI Gene ID713
GeneCardsC1QB
Human Protein AtlasC1QB
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer
InteractionsAIF1, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections248 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Targeting SASP-Complement Amplification Through HIF-1α Downs
Score: 0.79
Selective blockade of classical-pathway activation downstrea
Score: 0.75
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I
Score: 0.75
Complement-SASP Amplification Cascade as Mechanistic Link
Score: 0.74
Excessive C1q/C3/CR3 complement cascade activation initiates
Score: 0.72
Microglia and complement sustain post-Aβ neurodegeneration a
Score: 0.69
Microglial TREM2 state determines whether C1q-tagged substra
Score: 0.67
C1q-TREM2 Competition for Phosphatidylserine as Pruning Chec
Score: 0.67
APOE4-microglial complement signaling causes cholinergic-enr
Score: 0.63
C1q has spatially distinct functions, with synapse-bound C1q
Score: 0.63
Female microglia exhibit heightened complement gene expressi
Score: 0.61
C1q effector output is determined more by binding partner id
Score: 0.61
H2: Perforant Path Synapse Loss via Early Complement Cascade
Score: 0.61
Selective C1q-CRP vs. C1q-IgG Axis Inhibition
Score: 0.60
APOE isoform modifies the C1q binding landscape, biasing C1q
Score: 0.59
Direct NF-κB Transcriptional Regulation of C1q Genes in Micr
Score: 0.57
Combined NAMPT-Alectinib Targeting of SASP-Complement Cascad
Score: 0.55
C1q shows synapse-class-specific roles, with inhibitory vers
Score: 0.53
Alectinib-C1q Complex Hijacks TREM2's Synaptic Protective Bi
Score: 0.50
Kinase Inhibitor-C1q Structural Convergence for Bifunctional
Score: 0.46
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Knowledge Graph (12 edges)

C1QB interacts_with MET
C1QB interacts_with C1Q
CTSH interacts_with C1QB
C1QB activates SOD1
C1QB interacts_with HSP27
CCR1 regulates C1QB
MRC1 regulates C1QB
C1QB regulates CD38
C1QB regulates CD163
C1QB regulates CXCL10

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