gene

SMO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

2Hypotheses

0Analyses

41Outgoing

23Incoming

2Experiments

0Debates

Summary

Page for SMO — Smoothened, Frizzled Class Receptor

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🧬 Gene Info

Gene Symbol	SMO
Full Name	Smoothened, Frizzled Class Receptor
Chromosome	7q32.1
Protein Type	Receptor
Function	encodes a 793 amino acid class F G protein-coupled receptor (GPCR) that serves as the essential signal transducer of the Hedgehog (Hh) signaling pathway.
Primary Expression	neural progenitor cells of the ventricular zone, the external granular layer of the cerebellum, and the subventricular zone (SVZ)
Amino Acids	793 aa
Exons	12
Pathways	Apoptosis, Hedgehog
Ensembl ID	ENSG00000128602
GeneCards	SMO
Human Protein Atlas	SMO
Gαi coupling	SMO activates heterotrimeric Gi proteins, reducing cAMP and modulating PKA activity independently of GLI
Ca²⁺ signaling	SMO-Gαi coupling triggers phospholipase C (PLC) activation and inositol trisphosphate (IP3)-dependent Ca²⁺ release from the ER
Small GTPases	SMO activates RhoA and Rac1 to regulate cytoskeletal dynamics, growth cone guidance, and axonal pathfinding
Associated Diseases	ALS, Ameloblastoma, Cancer, Carcinoma, Medulloblastoma
Interactions	APOPTOSIS, BCL2, CANCER, GLI1, GLI2, SHH
KG Connections	64 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SMO — Smoothened, Frizzled Class Receptor

gene · 1600 words

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Pathway Diagram

graph TD
    SMO["SMO"]
    AMELOBLASTOMA{"AMELOBLASTOMA"}
    SMO -->|"associated with"| AMELOBLASTOMA
    Ms{"Ms"}
    SMO -->|"therapeutic target"| Ms
    Apoptosis(["Apoptosis"])
    SMO -->|"therapeutic target"| Apoptosis
    Angiogenesis(["Angiogenesis"])
    SMO -->|"therapeutic target"| Angiogenesis
    GENES["GENES"]
    SMO -->|"therapeutic target"| GENES
    SMO -->|"contributes to"| Apoptosis
    SMO -->|"contributes to"| Angiogenesis
    APOPTOSIS["APOPTOSIS"]
    SMO -->|"contributes to"| APOPTOSIS
    BRAF["BRAF"]
    SMO -->|"expressed in"| BRAF
    neurodegeneration["neurodegeneration"]
    SMO -->|"implicated in"| neurodegeneration
    BRAF -->|"therapeutic target"| SMO
    BRAF -->|"expressed in"| SMO
    APOPTOSIS -->|"contributes to"| SMO
    GENES -->|"expressed in"| SMO
    AND["AND"]
    AND -->|"expressed in"| SMO
    style SMO fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

Target	Relation	Type	Str
AMELOBLASTOMA	associated_with	disease	0.85
Ameloblastoma	associated_with	disease	0.85
Hedgehog	therapeutic_target	pathway	0.80
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Sonic Hedgehog	therapeutic_target	pathway	0.70
Carcinoma	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Medulloblastoma	implicated_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	implicated_in	disease	0.65
Carcinoma	implicated_in	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Carcinoma	inhibits	disease	0.65
Colorectal Cancer	activates	disease	0.65
APOPTOSIS	therapeutic_target	gene	0.60
GENES	expressed_in	gene	0.60
GENES	therapeutic_target	gene	0.60
Apoptosis	contributes_to	pathway	0.60
Angiogenesis	contributes_to	pathway	0.60
Apoptosis	activates	pathway	0.60
Hedgehog	activates	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Raf	therapeutic_target	protein	0.60
APOPTOSIS	contributes_to	gene	0.60
AND	expressed_in	gene	0.60
GLI2	activates	gene	0.60
BRAF	expressed_in	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Angiogenesis	therapeutic_target	pathway	0.60
Hedgehog	implicated_in	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
Invasion	therapeutic_target	pathway	0.60
Stem Cell	therapeutic_target	pathway	0.60
Tumor Microenvironment	therapeutic_target	pathway	0.60
Immunotherapy	therapeutic_target	pathway	0.60
ALS	associated_with	disease	0.60
EZH2	therapeutic_target	gene	0.60
BRAF	therapeutic_target	gene	0.60

Incoming (23)

Source	Relation	Type	Str
genes-smo	linked_to	wiki_page	1.00
BRAF	therapeutic_target	gene	0.70
CANCER	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.60
BCL2	activates	gene	0.60
SHH	inhibits	gene	0.60
GLI1	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
WNT	therapeutic_target	gene	0.60
BRD4	therapeutic_target	gene	0.60
BAD	therapeutic_target	gene	0.60
DES	therapeutic_target	gene	0.60
BRAF	implicated_in	gene	0.60
AND	therapeutic_target	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
GENES	expressed_in	gene	0.60
CANCER	implicated_in	gene	0.60
BRAF	expressed_in	gene	0.60
SHH	therapeutic_target	gene	0.60
MYC	co_expressed_with	gene	0.50
SHH	co_expressed_with	gene	0.50
BRAF	co_expressed_with	gene	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Osmotic Gradient Restoration via Selective AQP1 Enhancement	0.680	neurodegeneration	Perivascular spaces and glymphatic clear
Lysosomal Accumulation-Induced V-ATPase Inhibition (Osmotic	0.470	neurodegeneration	Why do structurally diverse sugars (treh

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.900	0.50	aortic endothelial cells	proposed	$6,550,000
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
AQP1 differentially orchestrates endothelial cell senescence. [PMID:39180980]	Shabanian K, Shabanian T, Karsai G, Pont	Redox Biol	2024	1
Non-Aquaporin Water Channels. [PMID:36717505]	Huang B, Wang H, Yang B	Adv Exp Med Biol	2023	1
Aquaporins in Nervous System. [PMID:28258567]	Xu M, Xiao M, Li S, Yang B	Adv Exp Med Biol	2017	1
Aquaporins in the Spinal Cord. [PMID:27941618]	Oklinski MK, Skowronski MT, Skowronska A	Int J Mol Sci	2016	1
Aquaporin gating. [PMID:16837191]	Hedfalk K, Törnroth-Horsefield S, Nyblom	Curr Opin Struct Biol	2006	1
Panax notoginseng saponins protect the blood-brain barrier against oxidative str [PMID:41763432]	Fan L, Qu S, Miao C, Wu D, Rao Y et al.	Int J Biol Macromol	2026	0
Stomatin encapsulates aquaporin-1 and urea transporter-B in the erythrocyte memb [PMID:41921000]	Vallese F, Li H, Barazzuol L, Calì T, Cl	Sci Adv	2026	0
Aquaporin membrane channels in the hepatobiliary tract: a model of complexity an [PMID:41926019]	Portincasa P, Khalil M, Calamita G	Intern Emerg Med	2026	0
Glycosomal Aquaglyceroporin 1 dual role in iron homeostasis and antimony suscept [PMID:41926379]	Boy RL, Zampieri RA, Aoki JI, Coelho AC,	PLoS Negl Trop Dis	2026	0
Aquaporin-1 Facilitates Macrophage M1 Polarization by Enhancing Glycolysis Throu [PMID:39365391]	["Diao R", "Lv W", "Wang Y", "Shen Q", "	Inflammation	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. [PMID:34670044]	Morelle J, Marechal C, Yu Z, Debaix H, C	The New England journal of med	2021	0
Discovery of novel diarylamides as orally active diuretics targeting urea transp [PMID:33532188]	["Zhang S", "Zhao Y", "Wang S", "Li M",	Acta pharmaceutica Sinica. B	2021	0
Physiological and pathological impact of AQP1 knockout in mice. [PMID:31023968]	Hua Y, Ying X, Qian Y, Liu H, Lan Y, Xie	Bioscience reports	2019	0
The potential role of aquaporin 1 on aristolochic acid I induced epithelial mese [PMID:29215709]	["Li J", "Zhang M", "Mao Y", "Li Y", "Zh	Journal of cellular physiology	2018	0
Cardiotrophin-1 predicts death or heart failure following acute myocardial infar [PMID:17045183]	["Khan S", "Kelly D", "Quinn P", "Davies	Journal of cardiac failure	2006	0
Regulation of mitosis in response to damaged or incompletely replicated DNA requ [PMID:16079276]	["Purdy A", "Uyetake L", "Cordeiro M", "	Journal of cell science	2005	0
Physiological roles of aquaporins in the choroid plexus. [PMID:15949534]	Boassa D, Yool AJ	Current topics in developmenta	2005	0
Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulum. [PMID:15189143]	["Toyoshima C", "Inesi G"]	Annual review of biochemistry	2004	0
Su e of the yeast F1Fo-ATP synthase forms homodimers. [PMID:12377768]	["Brunner S", "Everard-Gigot V", "Stuart	The Journal of biological chem	2002	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMO in their description or question text

No additional research found