gene

actn2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about actn2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

35Outgoing

10Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	ACTN2
Full Name	Actinin Alpha 2
Chromosome	1q42.13
Function	ACTN2 (Actinin alpha 2) is an actin-binding protein belonging to the spectrin superfamily.
Primary Expression	ACTN2 is expressed in neurons, particularly in dendritic shafts and postsynaptic densities
Subcellular Localization	excitatory synapses
Pathways	Camp Signaling, Chaperone
UniProt ID	P35609
Ensembl ID	ENSG00000143631
GeneCards	ACTN2
Human Protein Atlas	ACTN2
Associated Diseases	Cardiomyopathy, neuromuscular disorders
Interactions	Actin, App, MTOR
KG Connections	38 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: actn2 — AlphaFold P35609 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ACTN2 — Actinin Alpha 2

gene · 735 words

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Pathway Diagram

graph TD
    ACTN2["ACTN2"]
    ACTN2 -->|"activates"| Senescence["Senescence"]
    ACTN2 -->|"regulates"| Alzheimer["Alzheimer"]
    ACTN2 -->|"regulates"| Dementia["Dementia"]
    ACTN2 -->|"regulates"| Aging["Aging"]
    ACTN2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    ACTN2 -->|"activates"| Mtor["Mtor"]
    ACTN2 -->|"activates"| Stem_Cell["Stem Cell"]
    ACTN2 -->|"regulates"| ALZHEIMER["ALZHEIMER"]
    MTOR["MTOR"] -->|"activates"| ACTN2
    FHL1["FHL1"] -->|"regulates"| ACTN2
    AGING["AGING"] -->|"regulates"| ACTN2
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| ACTN2
    PDE4D["PDE4D"] -->|"regulates"| ACTN2
    ALZHEIMER -->|"regulates"| ACTN2
    DEMENTIA["DEMENTIA"] -->|"regulates"| ACTN2
    EGFR["EGFR"] -->|"regulates"| ACTN2

Outgoing (35)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ACTN2	data_in	dataset_row	0.00
Dementia	regulates	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Senescence	activates	disease	0.65
Mtor	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
CLU	regulates	gene	0.60
PDE4D	regulates	gene	0.60
MAPT	regulates	gene	0.60
EGFR	regulates	gene	0.60
GRIA3	regulates	gene	0.60
MTOR	activates	gene	0.60
FHL1	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
AGING	regulates	gene	0.60
App	regulates	protein	0.60
CRISPR-Cas	participates_in	pathway	0.60
Cardiomyocyte	activates	cell_type	0.60
Actin	activates	protein	0.60
Egfr	regulates	protein	0.60
App	activates	protein	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Camp Signaling	regulates	pathway	0.60
Rb	regulates	protein	0.60
Stem Cell	expressed_in	cell_type	0.55
GRIA3	regulates	gene	0.50
PDE4D	regulates	gene	0.50
Camp Signaling	regulates	pathway	0.50
MAPT	regulates	gene	0.50
FHL1	regulates	gene	0.50
mTOR	activates	entity	0.50
Chaperone	activates	pathway	0.50

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ACTN2	data_in	dataset_row	0.00
genes-actn2	describes	wiki	0.95
ALZHEIMER	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
EGFR	regulates	gene	0.60
MTOR	activates	gene	0.60
AGING	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
FHL1	regulates	gene	0.60
PDE4D	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning actn2 in their description or question text

No additional research found