concept

ASTROGLIOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ASTROGLIOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

2Analyses

33Outgoing

46Incoming

0Experiments

4Debates

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💡 Concept Info

Name	ASTROGLIOSIS
Key Genes/Proteins	APP, AQP4, BRAF, GADD45G
Related Diseases	ASTROCYTE REACTIVITY, AUTOPHAGY, DEMENTIA, GAUCHER DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Reactive Astrogliosis

mechanism · 1707 words

→

Pathway Diagram

graph TD
    ASTROGLIOSIS["ASTROGLIOSIS"]
    ASTROGLIOSIS -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    ASTROGLIOSIS -->|"contributes to"| Disease_Progression["Disease Progression"]
    ASTROGLIOSIS -->|"interacts"| DEMENTIA["DEMENTIA"]
    ASTROGLIOSIS -->|"activates"| MICROGLIA["MICROGLIA"]
    ASTROGLIOSIS -->|"inhibits"| GFAP["GFAP"]
    Gap26["Gap26"] -->|"inhibits"| ASTROGLIOSIS
    TET2["TET2"] -->|"inhibits"| ASTROGLIOSIS
    HEXB["HEXB"] -->|"causes"| ASTROGLIOSIS
    GADD45G["GADD45G"] -->|"promotes"| ASTROGLIOSIS
    ASTROCYTE["ASTROCYTE"] -->|"regulates"| ASTROGLIOSIS
    STEM_CELLS["STEM CELLS"] -->|"causes"| ASTROGLIOSIS
    BRAF["BRAF"] -->|"activates"| ASTROGLIOSIS

Outgoing (33)

Target	Relation	Type	Str
Microstructural Changes	causes	phenotype	0.92
Chemical Changes	associated_with	phenotype	0.92
Scar Formation	associated_with	phenotype	0.90
Alzheimer's Disease	contributes_to	disease	0.90
Neurodegeneration	associated_with	process	0.90
Alzheimer Disease	associated_with	disease	0.90
Alzheimer's Disease	biomarker_for	disease	0.80
Disease Progression	contributes_to	phenotype	0.75
NEURON	activates	cell_type	0.70
GFAP	inhibits	gene	0.65
GFAP	regulates	gene	0.65
MICROGLIA	activates	cell_type	0.65
STROKE	targets	disease	0.65
CORPUS CALLOSUM	interacts_with	brain_region	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
DEMENTIA	interacts_with	disease	0.65
MICROGLIAL ACTIVATION	activates	phenotype	0.65
MICROGLIAL ACTIVATION	treats	phenotype	0.65
MTOR	regulates	gene	0.65
NEUROINFLAMMATION	activates	phenotype	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
JAK2	inhibits	gene	0.65
JAK2	activates	gene	0.65
GFAP	depleted_in	gene	0.55
AUTOPHAGY	participates_in	phenotype	0.55
AUTOPHAGY	implicated_in	phenotype	0.55
SPINAL CORD	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.45
STRIATUM	associated_with	brain_region	0.45
BARICITINIB	associated_with	drug	0.45
SEMAGLUTIDE	associated_with	drug	0.45
CORTEX	associated_with	brain_region	0.45
BRAINSTEM	associated_with	brain_region	0.45

Incoming (46)

Source	Relation	Type	Str
32762702	causes	paper	0.90
BDNF Deficiency	causes	phenotype	0.88
NA/H EXCHANGER	upregulates	protein	0.85
Gap26	inhibits	compound	0.85
Gap26	associated_with	compound	0.85
TET2	inhibits	gene	0.85
GADD45G	promotes	gene	0.80
HEXB	causes	gene	0.80
Gap26	inhibits	compound	0.80
GFAP	indicates	biomarker	0.70
YKL-40	indicates	protein	0.70
SPINAL CORD	treats	brain_region	0.70
NEURONS	regulates	cell_type	0.70
SPINAL CORD	regulates	brain_region	0.70
MAPK	causes	gene	0.70
STAT3	causes	gene	0.65
TAU	activates	protein	0.65
TAU	treats	protein	0.65
GAUCHER DISEASE	interacts_with	disease	0.65
STEM CELLS	causes	cell_type	0.65
ASTROCYTE	regulates	cell_type	0.65
ASTROCYTE	inhibits	cell_type	0.65
BRAF	activates	gene	0.65
AQP4	exacerbates	gene	0.65
ASTROCYTE	causes	cell_type	0.65
ASTROCYTE REACTIVITY	causes	phenotype	0.65
ASTROCYTE REACTIVITY	targets	phenotype	0.65
ASTROCYTE	activates	cell_type	0.65
NEURONS	inhibits	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
SPINAL CORD	inhibits	brain_region	0.65
GRN	exacerbates	gene	0.65
NEURON	interacts_with	cell_type	0.65
NECROPTOSIS	inhibits	phenotype	0.65
AQP4	inhibits	gene	0.65
SPINAL CORD INJURY	inhibits	disease	0.65
GADD45G	causes	gene	0.64
GFAP	biomarker_for	gene	0.60
STAT3	implicated_in	gene	0.55
GLIAL FIBRILLARY ACIDIC PROTEIN	associated_with	biomarker	0.50
APP	associated_with	gene	0.50
INTERNEURONS	associated_with	cell_type	0.50
BASAL GANGLIA	associated_with	brain_region	0.45
CORPUS CALLOSUM	associated_with	brain_region	0.45
DENTATE GYRUS	associated_with	brain_region	0.45
TEMPORAL LOBE	associated_with	brain_region	0.45