protein 998 words KG: APOC3PROTEIN
Contents

APOC3 Protein

🔬 Protein Info
Gene SymbolAPOC3
Full NameApolipoprotein C-III
AliasesApoC-III
Chromosome11q23.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionHepatocytes in the liver (highest expression)
Subcellular Localization** | Secreted, plasma lipoprotein particles |
Molecular Weight8.8 kDa
Amino Acids79 aa
PathwaysCholesterol
NCBI Gene ID345
Ensembl IDENSG00000110245
GeneCardsAPOC3
Human Protein AtlasAPOC3
Cerebrospinal fluid presenceAPOC3 is detected in cerebrospinal fluid, suggesting local production or transport across the blood-brain barrier.
Associated DiseasesAging, Als, Atherosclerosis, Cardiovascular
InteractionsABCA1, ABCA2, APOA1, APOC1, APOC2, APOD
KG Connections100 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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Knowledge Graph

Related Hypotheses (6)

SASP-Mediated Complement Cascade Amplification
Score: 0.95
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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