concept

VALPROIC ACID

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VALPROIC ACID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

0Hypotheses

0Analyses

50Outgoing

10Incoming

0Experiments

0Debates

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💡 Concept Info

Name	VALPROIC ACID
Key Genes/Proteins	AKT, HDAC3, LRRK2, PI3K
Related Diseases	DOPAMINE, FERROPTOSIS, INFLAMMATION, NECROPTOSIS, NEURODEGENERATION
Related Pathways	PI3K/AKT PATHWAY

Pathway Diagram

graph TD
    VALPROIC_ACID[VALPROIC ACID]
    VALPROIC_ACID -->|activates| OXPHOS[OXPHOS]
    VALPROIC_ACID -->|causes| hyperammonemia[hyperammonemia]
    VALPROIC_ACID -->|treats| Chronic_Tendon_Injuries[Chronic Tendon Injuries]
    VALPROIC_ACID -->|inhibits| Necroptosis[Necroptosis]
    VALPROIC_ACID -->|activates| Oxidative_Phosphorylation[Oxidative Phosphorylation]
    VALPROIC_ACID -->|treats| Chronic_Tendon_Injury[Chronic Tendon Injury]
    VALPROIC_ACID -->|treats| autism[autism]
    VALPROIC_ACID -->|treats| neuroinflammation[neuroinflammation]
    VALPROIC_ACID -->|modulates| ferroptosis[ferroptosis]
    VALPROIC_ACID -->|inhibits| PI3K[PI3K]
    NEURON[NEURON] -->|inhibits| VALPROIC_ACID

Outgoing (72)

Target	Relation	Type	Str
OXPHOS	activates	pathway	0.92
hyperammonemia	causes	phenotype	0.90
Chronic Tendon Injuries	treats	disease	0.90
Necroptosis	inhibits	process	0.90
Oxidative Phosphorylation	activates	pathway	0.85
Chronic Tendon Injury	treats	disease	0.80
neuroinflammation	treats	disease	0.70
autism	treats	disease	0.70
ferroptosis	modulates	pathway	0.70
OXIDATIVE STRESS	activates	phenotype	0.65
NECROPTOSIS	activates	phenotype	0.65
NECROPTOSIS	inhibits	phenotype	0.65
OXIDATIVE STRESS	treats	phenotype	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
LRRK2	activates	gene	0.65
PI3K	inhibits	gene	0.65
SPINAL CORD INJURY	inhibits	disease	0.65
SPINAL CORD	inhibits	brain_region	0.65
epigenetic regulation	modulates	pathway	0.60
HDAC	inhibits	gene	0.60
DNA	regulates	gene	0.60
HDAC	regulates	gene	0.60
DNA	modulates	gene	0.60
NF-kB signaling	modulates	pathway	0.60
CHRNA7	causes	gene	0.60
CHRNA7	expressed_in	gene	0.60
HDAC3	activates	gene	0.60
STAT1	activates	gene	0.60
HDAC3	inhibits	gene	0.60
STAT1	inhibits	gene	0.60
STAT1	regulates	gene	0.60
STAT1	treats	gene	0.60
TNF	biomarker_for	gene	0.60
TNF	treats	gene	0.60
RELN	activates	gene	0.60
RELN	inhibits	gene	0.60
CHRNA7	regulates	gene	0.60
CHRNA7	modulates	gene	0.60
necroptosis	modulates	pathway	0.60
ACSL4	inhibits	gene	0.60
GSH	activates	gene	0.60
GSH	regulates	gene	0.60
GSH	treats	gene	0.60
unfolded protein response	modulates	pathway	0.60
GSH	inhibits	gene	0.60
GPX4	treats	gene	0.60
TFR1	treats	gene	0.60
GPX4	inhibits	gene	0.60
ACSL4	activates	gene	0.60
SLC7A11	activates	gene	0.60

Incoming (10)

Source	Relation	Type	Str
NEURON	inhibits	cell_type	0.65
SPINAL CORD INJURY	associated_with	disease	0.45
NEURODEGENERATION	associated_with	disease	0.45
PI3K/AKT PATHWAY	associated_with	pathway	0.45
HDAC3	associated_with	gene	0.45
STAT1	associated_with	gene	0.45
INFLAMMATION	associated_with	phenotype	0.45
SPINAL CORD	associated_with	brain_region	0.45
MICROGLIA	associated_with	cell_type	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VALPROIC ACID in their description or question text

No additional research found