concept

ST8SIA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ST8SIA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

188Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ST8SIA1 is a concept in neurodegeneration research. Key relationships include: expressed in, regulates, inhibits. Associated with ALS, Aging, Alzheimer. Connected to 73 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ST8SIA1
Key Genes/Proteins	ABCA1, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Aav Vector, Amyloid

🔮 Predicted Structure: ST8SIA1 — AlphaFold Q92185 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

GD3 Synthase (ST8SIA1)

enzyme · 637 words

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Pathway Diagram

graph TD
    ST8SIA1["ST8SIA1"]
    ST8SIA1 -->|"expressed in"| GD3S["GD3S"]
    ST8SIA1 -->|"interacts"| ST3GAL2["ST3GAL2"]
    ST8SIA1 -->|"regulates"| ALS["ALS"]
    ST8SIA1 -->|"regulates"| Inflammation["Inflammation"]
    ST8SIA1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    ST8SIA1 -->|"activates"| Parkinson["Parkinson"]
    ST8SIA1 -->|"expressed in"| Neuroinflammation["Neuroinflammation"]
    h_12599989["h-12599989"] -->|"targets"| ST8SIA1
    ST3GAL2 -->|"interacts"| ST8SIA1
    COMPLEMENT["COMPLEMENT"] -->|"regulates"| ST8SIA1
    JUN["JUN"] -->|"regulates"| ST8SIA1
    NEURON["NEURON"] -->|"regulates"| ST8SIA1
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| ST8SIA1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| ST8SIA1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| ST8SIA1
    PARKINSON["PARKINSON"] -->|"activates"| ST8SIA1

Outgoing (120)

Target	Relation	Type	Str
Gd3 Synthase	associated_with	enzyme	0.95
Amyloid Plaque	inhibits	biomarker	0.95
GD3S	expressed_in	protein	0.95
Ganglioside GD3	encodes	compound	0.95
Amyloid-Beta Aggregation	inhibits	process	0.90
Amyloid Plaque Load	downregulates	biomarker	0.90
GD3 Synthase	expressed_in	protein	0.90
Cognitive Deficits	protects_against	phenotype	0.90
Alzheimer'S Disease	associated_with	disease	0.90
Memory	regulates	phenotype	0.90
B-series Gangliosides	product_of	compound	0.85
Ganglioside Metabolism	involved_in	pathway	0.85
Neurons	protects_against	cell_type	0.85
Gangliosides	product_of	compound	0.85
Memory Deficits	protects_against	phenotype	0.85
neurodegeneration	associated_with	disease	0.65
ST3GAL2	interacts_with	gene	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	regulates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Aging	inhibits	disease	0.65
Parkinson	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neurodegeneration	associated_with	disease	0.65
APP/PSEN1	interacts_with	gene	0.60
Amyloid-Beta	inhibits	protein	0.60
NEURODEGENERATION	associated_with	gene	0.60
APP	interacts_with	gene	0.60
GFAP	expressed_in	gene	0.60
Complement System	expressed_in	pathway	0.60
Cytokine	expressed_in	protein	0.60
B4GANLT1	associated_with	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60
INFLAMMATION	expressed_in	gene	0.60

Incoming (68)

Source	Relation	Type	Str
AAV Vector with shRNA	targets	compound	0.93
Aav Vector	targets	mechanism	0.90
h-12599989	targets	hypothesis	0.90
ST3GAL2	interacts_with	gene	0.65
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PARKINSON	activates	gene	0.60
PARKINSON	regulates	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
AMYLOID	inhibits	gene	0.60
COMPLEMENT	regulates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
NEUROTOXICITY	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
AGING	inhibits	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NEURON	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
GATA1	activates	gene	0.60
GATA2	activates	gene	0.60
RUNX1	activates	gene	0.60
ST3GAL2	activates	gene	0.60
ST3GAL2	regulates	gene	0.60
NEURODEGENERATION	activates	entity	0.60
NEURODEGENERATION	associated_with	entity	0.60
RNA	binds_to	gene	0.60
JUN	regulates	gene	0.60
GFAP	expressed_in	gene	0.60
PSEN1	interacts_with	gene	0.60
B4GALNT1	regulates	gene	0.60
NEUROINFLAMMATION	expressed_in	gene	0.60
APP/PSEN1	interacts_with	gene	0.60
GD3S	activates	gene	0.60
GD3S	regulates	gene	0.60
AND	associated_with	gene	0.60
B4GANLT1	associated_with	gene	0.60
GD3S	interacts_with	gene	0.60
GD3S	protects_against	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
RNA	regulates	gene	0.60
APP	interacts_with	gene	0.60
Spinal Cord	associated_with	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.921

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

closed · Rounds: 5 · Score: 0.93 · 2026-04-11

Related Research

Hypotheses and analyses mentioning ST8SIA1 in their description or question text

No additional research found