gene

STAT5B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT5B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

15Outgoing

11Incoming

0Experiments

0Debates

Summary

Signal Transducer and Activator of Transcription 5B - critical cytokine signaling transcription factor in neurons, glia, and immune cells

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🧬 Gene Info

Gene Symbol	STAT5B
Full Name	Signal Transducer and Activator of Transcription 5B
Chromosome	12p13.31
Function	encodes a protein of approximately 787 amino acids.
Amino Acids	787 aa
Exons	19
Pathways	JAK-STAT, NF-κB
UniProt ID	[P51692](https://www.uniprot.org/uniprot/P51692)
Ensembl ID	ENSG00000173728
GeneCards	STAT5B
Human Protein Atlas	STAT5B
STAT-binding sites	Autoregulation by STAT5 signaling
NF-κB elements	Integration with inflammatory signals
Cell-type specific enhancers	Direct immune and neuronal expression
TATA box	Initiator-driven transcription
Associated Diseases	Cancer
KG Connections	25 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STAT5B Gene

gene · 1304 words

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Pathway Diagram

graph TD
    STAT5B["STAT5B"]
    Cancer{"Cancer"}
    STAT5B -->|"associated_with"| Cancer
    PFKFB3(["PFKFB3"])
    STAT5B -->|"associated_with"| PFKFB3
    PD_L1(["PD-L1"])
    STAT5B -->|"associated_with"| PD_L1
    Nf__b["Nf-Kappab"]
    STAT5B -->|"associated_with"| Nf__b
    Pi3K_Akt["Pi3K/Akt"]
    STAT5B -->|"associated_with"| Pi3K_Akt
    Notch["Notch"]
    STAT5B -->|"associated_with"| Notch
    MS4A4A(["MS4A4A"])
    MS4A4A -->|"associated_with"| STAT5B
    CCR8(["CCR8"])
    CCR8 -->|"associated_with"| STAT5B
    LAG3(["LAG3"])
    LAG3 -->|"associated_with"| STAT5B
    COMPLEMENT(["COMPLEMENT"])
    COMPLEMENT -->|"associated_with"| STAT5B
    style STAT5B fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (15)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
PD-L1	associated_with	gene	0.60
Nf-Κb	associated_with	pathway	0.60
Pi3K/Akt	associated_with	pathway	0.60
Notch	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Epithelial	associated_with	cell_type	0.60
Macrophage	associated_with	cell_type	0.60
Akt	associated_with	protein	0.60
Ras	associated_with	protein	0.60
PFKFB3	associated_with	gene	0.60
Pi3K	associated_with	protein	0.60
Il-6	associated_with	protein	0.60
Stat3	associated_with	protein	0.60

Incoming (11)

Source	Relation	Type	Str
RPL17	binds	gene	0.80
MS4A4A	associated_with	gene	0.60
CCR8	associated_with	gene	0.60
LAG3	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
CD163	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
KRAS	associated_with	gene	0.60
HEDGEHOG	associated_with	gene	0.60
NOTCH	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STAT5B in their description or question text

No additional research found