gene 2,128 words KG: PRKCI
Contents

PRKCI

🧬 Gene Info
Gene SymbolPRKCI
Chromosome3q26.2
Protein TypeKinase
Functionencodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases.
Subcellular LocalizationPRKCI localizes to multiple cellular compartments:
PathwaysOxidative Stress, Apoptosis, Akt, Ferroptosis, Dna Methylation
Ensembl IDENSG00000163558
GeneCardsPRKCI
Human Protein AtlasPRKCI
ATP bindingThe kinase domain binds ATP as a phosphate donor
Protein kinase activityCatalyzes phosphorylation of target proteins
Phospholipid bindingResponds to phospholipid signals (but not DAG)
Metal ion bindingRequires magnesium ions for catalytic activity
Zinc ion bindingContains zinc finger domains for protein interactions
Associated Diseasesneurodegeneration
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, NEURON
KG Connections24 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.86
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Extracellular Matrix Stiffness Modulation
Score: 0.69
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_target
DNA Methylation
entity · KG edge: therapeutic_target
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: therapeutic_target

Knowledge Graph (12 edges)

APP therapeutic_target PRKCI
PRKCI activates AKT
SORL1 therapeutic_target PRKCI
PRKCI therapeutic_target VDAC1
PRKCI therapeutic_target IL16
ALZHEIMER'S DISEASE activates PRKCI
APOPTOSIS therapeutic_target PRKCI
AND activates PRKCI
APP/PS1 therapeutic_target PRKCI
OXIDATIVE STRESS therapeutic_target PRKCI

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