gene

NICASTRIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NICASTRIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

50Outgoing

24Incoming

0Experiments

0Debates

Summary

Page for NICASTRIN Gene

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🧬 Gene Info

Gene Symbol	NCSTN
Aliases	NICASTRIN
Chromosome	1p31.3
Protein Family	Pen-2 family (γ-secretase complex)
Function	Complex Assembly: Nicastrin acts as a scaffold for γ-secretase complex assembly in the ER
Primary Expression	Endoplasmic reticulum, Golgi apparatus, cell membrane
Subcellular Localization	Endoplasmic reticulum, Golgi apparatus, cell membrane
Molecular Weight	79 kDa
Amino Acids	709 aa
Exons	21
Pathways	NF-κB
UniProt ID	Q92673
GeneCards	NCSTN
Human Protein Atlas	NCSTN
Variant 1 (canonical)	709 amino acids, widely expressed
Associated Diseases	ALS, Alzheimer, Neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, APH-1, APP, Aβ
KG Connections	75 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NICASTRIN — AlphaFold Q92673 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NICASTRIN Gene

gene · 3072 words

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Pathway Diagram

graph TD
    NICASTRIN["NICASTRIN"]
    Als["Als"]
    Alzheimer["Alzheimer"]
    Neurodegeneration["Neurodegeneration"]
    Notch["Notch"]
    AMYLOID["AMYLOID"]
    ALZHEIMER["ALZHEIMER"]
    PRESENILIN["PRESENILIN"]
    SYNAPSE["SYNAPSE"]
    NOTCH["NOTCH"]
    Synaptic_Plasticity["Synaptic Plasticity"]
    Neuron["Neuron"]
    APP["APP"]
    NICASTRIN -->|"regulates"| Als
    NICASTRIN -->|"regulates"| Alzheimer
    NICASTRIN -->|"therapeutic_tar"| Neurodegeneration
    NICASTRIN <-->|"interacts"| Alzheimer
    NICASTRIN <-->|"interacts"| Als
    NICASTRIN -->|"regulates"| Notch
    NICASTRIN -->|"regulates"| AMYLOID
    NICASTRIN -->|"regulates"| ALZHEIMER
    NICASTRIN -->|"regulates"| PRESENILIN
    NICASTRIN -->|"regulates"| SYNAPSE
    NICASTRIN -->|"therapeutic_tar"| NOTCH
    NICASTRIN -->|"regulates"| Synaptic_Plasticity
    NICASTRIN -->|"therapeutic_tar"| Notch
    NICASTRIN -->|"therapeutic_tar"| Neuron
    NICASTRIN <-->|"interacts"| AMYLOID
    NICASTRIN <-->|"interacts"| ALZHEIMER
    NICASTRIN <-->|"interacts"| APP
    NICASTRIN <-->|"interacts"| PRESENILIN
    NICASTRIN <-->|"interacts"| NOTCH
    NICASTRIN <-->|"interacts"| Notch
    style NICASTRIN fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (55)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Neurodegeneration	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Neurodegeneration	transports	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Als	transports	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
ALS	associated_with	disease	0.65
NOTCH	associated_with	gene	0.60
Amyloid	regulates	pathway	0.60
Amyloid	interacts_with	pathway	0.60
AMYLOID	inhibits	gene	0.60
Notch	inhibits	pathway	0.60
Fibroblast	inhibits	cell_type	0.60
Aβ	inhibits	protein	0.60
ALZHEIMER	transports	gene	0.60
Synaptic Plasticity	transports	pathway	0.60
Notch	transports	pathway	0.60
Neuron	transports	cell_type	0.60
App	transports	protein	0.60
Amyloid	transports	protein	0.60
Fibroblast	transports	cell_type	0.60
Notch	regulates	pathway	0.60
ALZHEIMER	regulates	gene	0.60
PRESENILIN	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
NOTCH	therapeutic_target	gene	0.60
Synaptic Plasticity	regulates	pathway	0.60
Notch	therapeutic_target	pathway	0.60
Neuron	therapeutic_target	cell_type	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
NOTCH	interacts_with	gene	0.60
Notch	interacts_with	pathway	0.60
Fibroblast	interacts_with	cell_type	0.60
Presenilin	transports	protein	0.60
Rb	transports	protein	0.60
APP	contributes_to	gene	0.60
AMYLOID	regulates	gene	0.60
Amyloid	associated_with	pathway	0.60
Notch	associated_with	pathway	0.60
APP	interacts_with	gene	0.60
Neurotransmitter Release	regulates	pathway	0.60

Incoming (24)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
Mannose	enhances	gene	0.80
Mannose	modulates	gene	0.70
ALZHEIMER	regulates	gene	0.60
PRESENILIN	interacts_with	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NOTCH	therapeutic_target	gene	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GENES	regulates	gene	0.60
PRESENILIN	regulates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
NOTCH	inhibits	gene	0.60
AMYLOID	transports	gene	0.60
PRESENILIN	transports	gene	0.60
NOTCH	transports	gene	0.60
SYNAPSE	transports	gene	0.60
APP	regulates	gene	0.60
APP	interacts_with	gene	0.60
APP	transports	gene	0.60
Neurodegeneration	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NICASTRIN in their description or question text

No additional research found