Contents

NICASTRIN Gene

🧬 Gene Info

Gene Symbol	NCSTN
Aliases	NICASTRIN
Chromosome	1p31.3
Protein Family	Pen-2 family (γ-secretase complex)
Function	Complex Assembly: Nicastrin acts as a scaffold for γ-secretase complex assembly in the ER
Primary Expression	Endoplasmic reticulum, Golgi apparatus, cell membrane
Subcellular Localization	Endoplasmic reticulum, Golgi apparatus, cell membrane
Molecular Weight	79 kDa
Amino Acids	709 aa
Exons	21
Pathways	NF-κB
UniProt ID	Q92673
GeneCards	NCSTN
Human Protein Atlas	NCSTN
Variant 1 (canonical)	709 amino acids, widely expressed
Associated Diseases	ALS, Alzheimer, Neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND, APH-1, APP
KG Connections	77 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING