protein

APH-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APH-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

0Outgoing

3Incoming

0Experiments

0Debates

Summary

Anterior Pharynx Defective 1 (APH-1) Protein

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🔬 Protein Info

Gene Symbol	APH
Protein Family	APH-1 family (γ-secretase complex)
Function	Anterior Pharynx Defective 1 (APH-1) is a conserved multipass transmembrane protein that serves as an essential stoichiometric component of the γ-secretase complex[@goutte2002]
Subcellular Localization	Endoplasmic reticulum, Golgi apparatus, plasma membrane
UniProt ID	Q9WVM4 (APH-1A), Q8WW43 (APH-1B)
GeneCards	APH
Human Protein Atlas	APH
Interactions	NICASTRIN, PEN-2, PRESENILIN
KG Connections	3 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — APH-1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5A63 — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q9WVM4 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Anterior Pharynx Defective 1 (APH-1) Protein

protein · 784 words

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Pathway Diagram

graph TD
    APH_1(["APH-1"])
    NICASTRIN["NICASTRIN"]
    PRESENILIN(["PRESENILIN"])
    PEN_2(["PEN-2"])

    NICASTRIN -->|"interacts with"| APH_1
    PRESENILIN -->|"interacts with"| APH_1
    PEN_2 -->|"interacts with"| APH_1

    style APH_1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style NICASTRIN fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style PRESENILIN fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style PEN_2 fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (3)

Source	Relation	Type	Str
NICASTRIN	interacts_with	gene	0.50
PRESENILIN	interacts_with	protein	0.50
PEN-2	interacts_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APH-1 in their description or question text

No additional research found