gene 841 words KG: MBD2
Contents

MBD2 Gene - Methyl-CpG Binding Domain Protein 2

🧬 Gene Info
Gene SymbolMBD2
Full NameMethyl-CpG Binding Domain Protein 2
AliasesPage for MBD2 Gene, Page for MBD2 Protein
Chromosome18q21.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain with particularly high levels in:
Molecular Weight46 kDa
Amino Acids80 aa
UniProt IDQ9UBT4
NCBI Gene ID8932
Ensembl IDENSG00000134046
OMIM605078
GeneCardsMBD2
Human Protein AtlasMBD2
Methyl-CpG binding domain (MBD)Located at the N-terminus (amino acids 144-206), this ~80 aa domain confers specificity for methylated CpG dinucleotides
Associated DiseasesMs
InteractionsABCB1, KMT2A
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
DNA Methylation
entity · KG edge: expressed_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: expressed_in
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: expressed_in
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: activates

Knowledge Graph (12 edges)

MBD2 activates ABCB1
MBD2 activates KMT2A
ADRA2A expressed_in MBD2
DNMT3B expressed_in MBD2
DNMT1 expressed_in MBD2
DNMT3A expressed_in MBD2
PI3K expressed_in MBD2
ADRA2B expressed_in MBD2
MBD2 expressed_in AKT
MBD2 expressed_in MAPK14

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