protein 1,107 words KG: MBD2PROTEIN
Contents

MBD2 Protein - Methyl-CpG Binding Domain Protein 2

🔬 Protein Info
Gene SymbolMBD2
Full NameMethyl-CpG Binding Domain Protein 2
AliasesPage for MBD2 Gene, Page for MBD2 Protein
Chromosome18q21.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain with particularly high levels in:
Molecular Weight46 kDa
Amino Acids80 aa
UniProt IDQ9UBT4
NCBI Gene ID8932
Ensembl IDENSG00000134046
OMIM605078
GeneCardsMBD2
Human Protein AtlasMBD2
Amyloid ProcessingMBD2 regulates genes involved in amyloid precursor protein (APP) processing and amyloid-beta production. Altered MBD2 activity may contribute to increased amyloidogenesis in AD brains.
Associated DiseasesMs
InteractionsABCB1, KMT2A
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.94
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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