gene 1,700 words KG: DLL1
Contents

DLL1 Gene

🧬 Gene Info
Gene SymbolDLL1
Full NameDelta-Like 1
Chromosome6q27
Functionencodes a transmembrane ligand of the Delta/Serrate/Lag-2 (DSL) family that activates Notch receptors through cell-cell contact.
Primary ExpressionBrain (hippocampus, cortex, SVZ), neural stem cells, neurons, astrocytes
Molecular Weight82 kDa
Amino Acids723 aa
Exons24
PathwaysNotch, Notch signaling
UniProt IDO00548
NCBI Gene ID28514
Ensembl IDENSG00000198719
OMIM604552
GeneCardsDLL1
Human Protein AtlasDLL1
Associated DiseasesAls, Autism
KG Connections25 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (9)

Notch and Gamma-Secretase Modulators for Parkinson's Di
company · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
CCL3 Gene
gene · KG edge: therapeutic_target
Class II Major Histocompatibility Complex Transactivato
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

NOS2 therapeutic_target DLL1
CCL3 therapeutic_target DLL1
ESR1 therapeutic_target DLL1
ABCB1 therapeutic_target DLL1
CIITA therapeutic_target DLL1
MYC regulates DLL1
DLL1 regulates BACE1
DLL1 regulates NDRG2
DLL1 regulates NLRP3
DLL1 associated_with NOTCH1

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