| Gene Symbol | CYSTATINC |
| Full Name | Cystatin C (CST3) |
| Aliases | CYSTATINCPROTEIN |
| Protein Type | Protein |
| Function | is a member of the type 2 cystatin family of cysteine protease inhibitors[@abrahamson1994]. |
| Subcellular Localization | ** | Extracellular, secreted |
| UniProt ID | Search UniProt |
| GeneCards | CYSTATINC |
| Human Protein Atlas | CYSTATINC |
| Amyloid Deposition | Mutant cystatin C forms amyloid deposits in cerebral blood vessel walls |
| Hemorrhage | Leads to lobar intracerebral hemorrhages, typically in elderly patients |
| Prevalence | The L68Q mutation is particularly common in Icelandic families (1 in 4,000 carriers) |
| Mechanism | The mutation promotes dimerization and amyloid fibril formation |
| Protective Effects | CST3 expression is increased in AD brain, potentially as a protective response to Aβ deposition |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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