| Gene Symbol | CNTFRGENE |
| Transmembrane Domain (311-335 aa) | A single pass α-helical transmembrane segment anchors the receptor to the plasma membrane. |
| Cytoplasmic Domain (336-372 aa) | Contains proline-rich motifs that interact with JAK kinases and facilitate downstream signaling cascade activation. |
| Central Nervous System | Motor neurons of the spinal cord and brainstem, hippocampal pyramidal neurons, cortical neurons, cerebellar Purkinje cells |
| Peripheral Nervous System | Sensory neurons, autonomic neurons |
| Non-neural Tissues | Skeletal muscle, heart, liver, adipose tissue |
| Bcl-2 family proteins | Upregulation of anti-apoptotic Bcl-2 and Bcl-xL |
| SOCS proteins | Negative feedback regulators |
| GFAP | Astrocytic response modulation |
| PLCγ | Calcium signaling and PKC activation |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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