concept

CHOLESTEROL HOMEOSTASIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOLESTEROL HOMEOSTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

1Analyses

2Outgoing

46Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	CHOLESTEROL HOMEOSTASIS

Pathway Diagram

graph TD
    CHOLESTEROL_HOMEOSTASIS[CHOLESTEROL HOMEOSTASIS]
    CYP46A1[CYP46A1] -->|regulates| CHOLESTEROL_HOMEOSTASIS
    SREBF2[SREBF2] -->|regulates| CHOLESTEROL_HOMEOSTASIS
    ABCA1[ABCA1] -->|participates in| CHOLESTEROL_HOMEOSTASIS
    LXR[LXR] -->|participates in| CHOLESTEROL_HOMEOSTASIS
    neurons[neurons] -->|active_in| CHOLESTEROL_HOMEOSTASIS
    SREBP2[SREBP2] -->|regulates| CHOLESTEROL_HOMEOSTASIS
    APOE[APOE] -->|regulates| CHOLESTEROL_HOMEOSTASIS
    APOE4[APOE4] -->|disrupts| CHOLESTEROL_HOMEOSTASIS
    YTHDF2[YTHDF2] -->|inhibits| CHOLESTEROL_HOMEOSTASIS
    HUNTINGTON[HUNTINGTON] -->|disrupts| CHOLESTEROL_HOMEOSTASIS

Outgoing (2)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.85
AUTOPHAGY	associated_with	process	0.80

Incoming (46)

Source	Relation	Type	Str
CYP46A1	regulates	gene	0.95
mitochondrial_transfer	contributes_to	mechanism	0.90
SREBF2	regulates	gene	0.90
neurons	active_in	cell_type	0.85
ABCA1	participates_in	gene	0.85
LXR	participates_in	gene	0.85
SREBP2	regulates	gene	0.85
YTHDF2	inhibits	protein	0.80
APOE	regulates	gene	0.80
HUNTINGTON	disrupts	disease	0.80
APOE	participates_in	gene	0.75
LAMP2	regulates	protein	0.75
neuroinflammation	involves	disease	0.75
APOE4	participates_in	gene	0.75
ATP	participates_in	gene	0.75
LDLR	regulates	gene	0.70
LRP1	participates_in	gene	0.65
CYP46A1	participates_in	gene	0.65
ABCG1	participates_in	gene	0.65
ABCA7	regulates	gene	0.60
HMGCR	involved_in	protein	0.60
CYP46A1	regulates	gene	0.60
TREM2	participates_in	gene	0.55
HMGCR	participates_in	gene	0.55
APP	participates_in	gene	0.55
LDLR	participates_in	gene	0.55
DGAT1	participates_in	gene	0.55
SOAT1	participates_in	gene	0.55
GABARAPL1	participates_in	gene	0.55
ABCA7	participates_in	gene	0.55
Alzheimer's disease	involves	disease	0.55
NPC1	participates_in	gene	0.55
oligodendrocytes	active_in	cell_type	0.55
LDHA	participates_in	gene	0.55
PKM	participates_in	gene	0.55
ACSL5	participates_in	gene	0.55
TNF	participates_in	gene	0.55
FASN	participates_in	gene	0.55
HK2	participates_in	gene	0.55
SQSTM1	participates_in	gene	0.55
SP1	participates_in	gene	0.55
SGMS1	participates_in	gene	0.55
astrocytes	active_in	cell_type	0.55
PS1	participates_in	gene	0.55
FE65	participates_in	gene	0.55
microglia	active_in	cell_type	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.90 · 2026-04-02

Related Research

Hypotheses and analyses mentioning CHOLESTEROL HOMEOSTASIS in their description or question text

No additional research found