concept

CGAS-STING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS-STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

281Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CGAS-STING PATHWAY
Key Genes/Proteins	CGAS, CXCL10
Related Diseases	ALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, ASTROCYTE REACTIVITY

Pathway Diagram

graph TD
    CGAS_STING_PATHWAY["CGAS-STING PATHWAY"]
    style CGAS_STING_PATHWAY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CGAS_STING_PATHWAY -->|"activates"| innate_immune_response["innate immune response"]
    CGAS_STING_PATHWAY -->|"involved_in"| Innate_Immunity["Innate Immunity"]
    CGAS_STING_PATHWAY -->|"promotes"| astrocyte_senescence["astrocyte senescence"]
    CGAS_STING_PATHWAY -->|"causes"| cardiac_inflammation(cardiac inflammation)
    CGAS_STING_PATHWAY -->|"causes"| ageing_related_inflammation(ageing-related inflammation)
    CGAS_STING_PATHWAY -->|"upregulates"| PRO_INFLAMMATORY_CYTOKINES([PRO-INFLAMMATORY CYTOKINES])
    CGAS_STING_PATHWAY -.->|"inhibits"| MTOR([MTOR])
    CGAS_STING_PATHWAY -->|"promotes"| neurodegeneration["neurodegeneration"]
    CGAS_STING_PATHWAY -->|"mediates"| Proinflammatory_Response["Proinflammatory Response"]
    CGAS_STING_PATHWAY -->|"activates"| Sterile_Inflammation["Sterile Inflammation"]
    Dna["Dna"] -->|"activates"| CGAS_STING_PATHWAY
    Mitophagy["Mitophagy"] -->|"interacts"| CGAS_STING_PATHWAY
    Substance_P([Substance P]) -.->|"inhibits"| CGAS_STING_PATHWAY
    Mitochondrial_DNA["Mitochondrial DNA"] -->|"activates"| CGAS_STING_PATHWAY
    substance_P([substance P]) -.->|"inhibits"| CGAS_STING_PATHWAY
    pathogenic_DNA([pathogenic DNA]) -->|"activates"| CGAS_STING_PATHWAY
    PINK1([PINK1]) -.->|"inhibits"| CGAS_STING_PATHWAY
    mitochondrial_DNA([mitochondrial DNA]) -->|"activates"| CGAS_STING_PATHWAY
    Damaged_Mitochondria(Damaged Mitochondria) -->|"activates"| CGAS_STING_PATHWAY
    Damaged_mitochondria["Damaged mitochondria"] -->|"activates"| CGAS_STING_PATHWAY

Outgoing (135)

Target	Relation	Type	Str
neurodegeneration	implicated_in	process	1.00
Innate Immunity	involved_in	process	0.95
Neuroinflammation	promotes	process	0.95
Neurodegeneration	promotes	process	0.95
innate immune response	activates	pathway	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
astrocyte senescence	promotes	process	0.92
neurodegeneration	promotes	process	0.90
cardiac inflammation	causes	phenotype	0.90
Neuroinflammation	mediates	process	0.90
Traumatic Brain Injury	involved_in	disease	0.90
ageing-related inflammation	causes	phenotype	0.90
Proinflammatory Response	mediates	process	0.90
Sterile Inflammation	activates	process	0.90
Neuroinflammation	contributes_to	process	0.90
Parkinson's Disease	contributes_to	disease	0.90
Neurodegeneration	contributes_to	process	0.90
PRO-INFLAMMATORY CYTOKINES	upregulates	protein	0.90
Pathogen Clearance	promotes	process	0.90
MTOR	inhibits	protein	0.90
tumor-derived DNA	regulates	phenotype	0.90
PD-L1	upregulates	protein	0.90
Autophagy	activates	process	0.90
neuroinflammation	mediates	process	0.90
neuroinflammation	regulates	process	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
Neurodegenerative Diseases	implicated_in	disease	0.90
Mitochondrial DNA	associated_with	biomarker	0.90
Aging	involved_in	phenotype	0.85
Parkinson'S Disease	contributes_to	disease	0.85
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.85
Abnormal Glial Activation	involved_in	process	0.85
Inflammatory Cytokine Expression	upregulates	process	0.85
Cellular Senescence	involved_in	process	0.85
Proinflammatory Response	activates	process	0.85
neuroinflammation	causes	phenotype	0.85
cellular senescence	promotes	process	0.85
systemic inflammation	promotes	phenotype	0.85
Low-Grade Inflammation	activates	process	0.85
Ataxia-Telangiectasia	contributes_to	disease	0.85
Dopaminergic neuronal loss	mediates	phenotype	0.85
PRO-INFLAMMATORY CYTOKINES	upregulates	protein	0.85
Neurodegenerative disorders	associated_with	disease	0.85
Ferroptosis	regulates	process	0.85
senescence	regulates	process	0.85
aging	associated_with	process	0.85
innate immune activation	activates	process	0.85
NLRP3 inflammasome activation	regulates	process	0.85
pulmonary fibrosis	promotes	disease	0.85
Inflammatory Cytokine Expression	upregulates	process	0.85

Incoming (146)

Source	Relation	Type	Str
Dna	activates	compound	0.95
Mitophagy	interacts_with	process	0.95
PGAM5	activates	protein	0.95
Cytosolic DNA buildup	activates	process	0.95
mtDNA efflux	activates	process	0.95
Substance P	inhibits	protein	0.93
Mitochondrial DNA	activates	compound	0.92
PINK1	inhibits	gene	0.90
Damaged Mitochondria	activates	phenotype	0.90
STING	associated_with	gene	0.90
pathogenic DNA	activates	gene	0.90
mitochondrial DNA	activates	protein	0.90
TDP-43 pathology	associated_with	mechanism	0.90
mitochondrial DNA release	activates	process	0.90
Mitochondrial Dna	activates	biomarker	0.90
41094684	senses	paper	0.90
41094684	plays a critical role in	paper	0.90
substance P	inhibits	protein	0.90
41892314	links	paper	0.90
Damaged mitochondria	activates	organelle	0.90
OMA1	activates	protein	0.90
RU.521	inhibits	drug	0.90
41892314	links DNA damage to	paper	0.90
IL-6-STAT3 PATHWAY	regulates	pathway	0.88
mtDNA	activates	biomarker	0.85
Disturbed intracellular trafficking	activates	process	0.85
Mitochondrial DNA Release	activates	process	0.85
Mitophagy	inhibits	process	0.85
BCL-2-Mediated Apoptotic Machinery	activates	process	0.85
STING	involved_in	protein	0.85
Mitochondrial dysfunction	activates	mechanism	0.85
Protein Phase Separation	activates	mechanism	0.85
H-151	inhibits	drug	0.85
Nuclear Dna	activates	biomarker	0.85
tumor-derived DNA	activates	gene	0.80
Impaired DNA repair	activates	mechanism	0.80
α-Synuclein aggregation	activates	mechanism	0.80
Effective Mitophagy	inhibits	process	0.80
FGF21	inhibits	protein	0.80
Cellular Stress Response	activates	process	0.75
TSG	inhibits	drug	0.70
DNA double-strand breaks	activates	process	0.70
dysfunctional mitophagy	activates	process	0.70
mitophagy	inhibits	process	0.70
damaged mitochondria	activates	cell_type	0.70
APOE3S/S	inhibits	gene	0.70
BCL2	activates	protein	0.70
microglia	expresses_in	cell_type	0.70
VPS13C	regulates	protein	0.70
ISCHEMIA	activates	disease	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
cGAS-STING Pathway Hyperactivation Mediates Tau Propagation	0.760	neurodegeneration	Gap 006 analysis (archived stub)
cGAS Inhibitors for ALS Therapeutics: Targeting Upstream mtD	0.380	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164]	Unknown		2025
The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238]	Unknown		2025
Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133]	Hyde VR, Zhou C, Fernandez JR, Chatterje	Cell reports	2025
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433]	Carling GK, Fan L, Foxe NR, Norman K, Wo	Neuron	2024
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623]	["Jin Meihua", "Shiwaku Hiroki", "Tanaka	Nature communications	2021

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CGAS-STING PATHWAY in their description or question text

No additional research found