| Gene Symbol | ABCD1PROTEIN |
| Protein Family | ABC transporter family D |
| Protein Type | Transporter |
| Function | is a peroxisomal membrane transporter protein essential for the import of very long-chain fatty acids (VLCFAs) into peroxisomes for β-oxidation[@mosser1993]. |
| Molecular Weight | ~66 kDa |
| Amino Acids | 660 amino acids |
| UniProt ID | P33897 |
| GeneCards | ABCD1PROTEIN |
| Human Protein Atlas | ABCD1PROTEIN |
| Six transmembrane helices | Form the translocation pore |
| Peroxisomal membrane topology | N- and C-termini face the cytosol |
| Substrate binding pocket | Located within the membrane |
| N-terminal NBD | Binds and hydrolyzes ATP |
| Walker A motif | Phosphate-binding loop (P-loop) |
| Walker B motif | Coordinates Mg²⁺ ion |
| Associated Diseases | Als, Ms |
| Interactions | ABCD2, ABCD3, ATP, BLOOD-BRAIN BARRIER DYSFUNCTION, CLDN5, CTNNB1 |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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