| Gene Symbol | TGFBR2 |
| Full Name | Transforming Growth Factor Beta Receptor 2 |
| Chromosome | 3p22.1 |
| Function | TGFBR2 (Transforming Growth Factor Beta Receptor 2) encodes the type II TGF-β receptor, a transmembrane serine/threonine kinase that is essential for TGF-β signaling. |
| Primary Expression | the brain: |
| Pathways | TGF-β, TGF-β signaling, PI3K, MAPK |
| UniProt ID | [P37173](https://www.uniprot.org/uniprot/P37173) |
| Ensembl ID | ENSG00000163513 |
| GeneCards | TGFBR2 |
| Human Protein Atlas | TGFBR2 |
| Neuronal survival | Anti-apoptotic signaling through multiple pathways |
| Neuroinflammation | Suppression of microglial activation |
| Synaptic plasticity | Regulation of dendritic spine formation |
| Astrocyte function | Modulation of astrocytic responses |
| Oligodendrocyte maturation | Promotes myelination |
| Associated Diseases | Als, Cancer, Carcinoma, Colorectal Cancer, Gastric Cancer |
| Interactions | AND, GENES, PIEZO1, SMAD2, TGF, TGFBR1 |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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