Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PV: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | PV |
| Key Genes/Proteins | ACC, ALS, AR, BIN1, CDK5, DRP1 |
| Related Diseases | Alzheimer's disease, autism spectrum disorder, epilepsy |
| Linked Hypotheses | 34 hypotheses |
Knowledge base pages for this entity
graph TD
PV[PV]
PV -->|expressed in| Inhibitory_Neurons[Inhibitory Neurons]
PV -->|promotes| motor_recovery[motor recovery]
PV -->|expressed in| SST[SST]
PV -->|expressed in| autism_spectrum_disorder[autism spectrum disorder]
PV -->|phosphorylates| epilepsy[epilepsy]
PNN[PNN] -->|activates| PV
ACC[ACC] -->|regulates| PV
HSPA1A[HSPA1A] -->|expressed in| PV
CDK5[CDK5] -->|activates| PV
DRP1[DRP1] -->|activates| PV
JAK2[JAK2] -->|causes| PV
NRG1[NRG1] -->|inhibits| PV| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PV | data_in | dataset_row | 0.00 |
| Inhibitory Neurons | expressed_in | cell_type | 0.95 |
| motor recovery | promotes | phenotype | 0.95 |
| autism spectrum disorder | expressed_in | disease | 0.70 |
| SST | inhibits | gene | 0.70 |
| SST | regulates | gene | 0.70 |
| SST | expressed_in | gene | 0.70 |
| epilepsy | interacts_with | disease | 0.60 |
| epilepsy | activates | disease | 0.60 |
| schizophrenia | associated_with | disease | 0.60 |
| epilepsy | inhibits | disease | 0.60 |
| epilepsy | associated_with | disease | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| SST | activates | gene | 0.60 |
| SST | biomarker_for | gene | 0.60 |
| SST | associated_with | gene | 0.60 |
| autism spectrum disorder | implicated_in | disease | 0.60 |
| autism spectrum disorder | inhibits | disease | 0.60 |
| Alzheimer's disease | inhibits | disease | 0.60 |
| Alzheimer's disease | causes | disease | 0.60 |
| Alzheimer's disease | interacts_with | disease | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| epilepsy | phosphorylates | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PV | data_in | dataset_row | 0.00 |
| PNN | activates | gene | 0.80 |
| ACC | regulates | gene | 0.70 |
| PNN | expressed_in | gene | 0.60 |
| ALS | co_expressed_with | gene | 0.60 |
| ACC | expressed_in | gene | 0.60 |
| PNN | inhibits | gene | 0.60 |
| GABA | inhibits | gene | 0.60 |
| PNN | translocates_to | gene | 0.60 |
| HSPA1A | expressed_in | gene | 0.60 |
| GDNF | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| CDK5 | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| CDK5 | phosphorylates | gene | 0.60 |
| JAK2 | causes | gene | 0.60 |
| JAK2 | interacts_with | gene | 0.60 |
| JAK2 | associated_with | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| BIN1 | causes | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| NRG1 | inhibits | gene | 0.60 |
| AR | associated_with | gene | 0.60 |
| NMDAR | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.747
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| SIRPα modulation in mouse models of Alzheimer's disease | validation | Alzheimer's disease | 0.900 | 0.00 | mouse models of Alzheimer's di | proposed | N/A |
| Autophagy receptor identification for stress granule elimination | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells under arsenite | proposed | N/A |
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
| Microglial SIRPα expression in human Alzheimer's disease tissue | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
| Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int | in_vivo | Alzheimer's disease | 0.765 | 0.55 | APP/PS1 mice 8-11 months (n=10 | proposed | $125,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Retinal Müller glia alterations and their impact on ocular glymphatic clearance [PMID:41603340] | Das G, Raghunathan R, Wang L | J Alzheimers Dis | 2026 | 0 |
| The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, [PMID:41226584] | ["Costea D", "Dobrin N", "Tataru C", "To | International journal of molec | 2025 | 0 |
| Longitudinal changes of blood-brain barrier and transcytolemmal water exchange p [PMID:40089221] | Xiong C, Yu Z, Yin Y | Neuroimage | 2025 | 0 |
| The future of biomarkers for vascular contributions to cognitive impairment and [PMID:40542975] | Lennon MJ, Karvelas N, Ganesh A | Geroscience | 2025 | 0 |
| Roles of NAD+ in Health and Aging. [PMID:37848251] | Lautrup S, Hou Y, Fang EF, Bohr VA | Cold Spring Harbor perspective | 2024 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| The different autophagy degradation pathways and neurodegeneration. [PMID:35134347] | Fleming A, Bourdenx M, Fujimaki M, Karab | Neuron | 2022 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasou [PMID:32999351] | Lee Y, Choi Y, Park EJ | Sci Rep | 2020 | 0 |
| Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive defi [PMID:30742114] | Unknown | Nature neuroscience | 2019 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PV in their description or question text
Score: 0.863 · Alzheimer's disease · 2026-04-07
## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling a
Score: 0.843 · molecular neurobiology · 2026-04-17
## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe
Score: 0.827 · Alzheimer's disease · 2026-04-16
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph
Score: 0.827 · Alzheimer's disease · 2026-04-05
## Mechanistic Overview Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance
Score: 0.797 · Alzheimer's disease · 2026-04-07
## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f
Score: 0.775 · Alzheimer's disease · 2026-04-02
## Molecular Mechanism and Rationale Parvalbumin-expressing (PV+) interneurons represent the most abundant class of GAB
Score: 0.747 · neurodegeneration · 2026-04-15
**Molecular Mechanism and Rationale** The complement system's classical pathway, initiated by C1q complex formation, re
Score: 0.743 · neurodegeneration · 2026-04-15
## Mechanistic Overview BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Interneuron Hypofuncti
Score: 0.659 · neurodegeneration · 2026-04-13
## Mechanistic Overview Complement C1QA Inhibition Synergizes with PV Interneuron Modulation starts from the claim that
Score: 0.622 · Alzheimer's disease · 2026-04-07
## Mechanistic Overview Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening to restore hippo
Score: 0.609 · neurodegeneration · 2026-04-16
## Mechanistic Overview Ketone-Based Metabolic Switching to Restore PV Interneuron Function starts from the claim that m
Score: 0.603 · Alzheimer's disease · 2026-04-05
## Mechanistic Overview Closed-loop transcranial alternating current stimulation to restore hippocampal-prefrontal gamma
Score: 0.596 · Alzheimer's disease · 2026-04-07
## Mechanistic Overview Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibition and block tau
Score: 0.564 · Alzheimer's disease · 2026-04-17
## Mechanistic Overview Closed-loop transcranial focused ultrasound with real-time gamma feedback to restore PV interneu
Score: 0.564 · Alzheimer's disease · 2026-04-20
## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore Anky