| Gene Symbol | TRPV5 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily V Member 5 |
| Chromosome | 7q33 |
| Protein Type | Channel |
| Function | encodes a highly calcium-selective ion channel that serves as the primary entry pathway for transcellular calcium transport in epithelial tissues. |
| Primary Expression | various regions including the hippocampus, cerebral cortex, and [cerebellum](/brain-regions/cer |
| Amino Acids | 730 aa |
| UniProt ID | Q9NHA2 |
| NCBI Gene ID | 56802 |
| Ensembl ID | ENSG00000165102 |
| GeneCards | TRPV5 |
| Human Protein Atlas | TRPV5 |
| N-terminal domain | Contains six ankyrin repeat domains (ARD), which are involved in protein-protein interactions and channel regulation |
| Pre-sensor loop | A distinctive feature of TRPV channels between transmembrane segments S1-S4 that functions as a voltage sensor |
| Transmembrane domain | Six transmembrane helices (S1-S6) with a pore loop between S5 and S6 forming the ion selectivity filter |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
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