protein 1,771 words KG: PPAR
Contents

PPAR (Peroxisome Proliferator-Activated Receptor)

🔬 Protein Info
Gene SymbolPPAR
Full NamePPAR (Peroxisome Proliferator-Activated Receptor)
AliasesPeroxisome Proliferator-Activated Receptor
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionneurons, astrocytes, microglia, and oligodendrocytes, where they modulate critical processes including neuroinflammation, mit
PathwaysApoptosis, Autophagy, Differentiation, Epigenetic, Lipid Metabolism
UniProt IDSearch UniProt
GeneCardsPPAR
Human Protein AtlasPPAR
Associated DiseasesAD, Als, Alzheimer, AMI, ARDS
Known Drugs/Compoundskaempferol, SDHHQ
InteractionsABCA1, ABCA7, ABCB1, ACSL4, Actin, AEP
KG Connections989 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (64)

Nucleolar Stress Response Normalization
Score: 0.65
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
← Prevpg 3/4Next →

Related Analyses (28)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (4)

TUG C-terminal fragment nuclear interactions
exploratory · proposed · Score: 0.85
Pathway analysis of aminophylline effects on neuronal signal
exploratory · proposed · Score: 0.70
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (7)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: expressed_in
ACE Gene
gene · KG edge: regulates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibits
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibits

Knowledge Graph (12 edges)

PPAR implicated_in obesity
PPAR implicated_in ARDS
PPAR implicated_in degenerative disease
PPAR implicated_in neurodegenerative disease
CLDN1 activates PPAR
PPAR activates TNF
PPAR activates OCLN
PPAR inhibits MLCK
AQP4 activates PPAR
PRKN activates PPAR

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.