protein 1,771 words KG: PPAR
Contents

PPAR (Peroxisome Proliferator-Activated Receptor)

🔬 Protein Info
Gene SymbolPPAR
Full NamePPAR (Peroxisome Proliferator-Activated Receptor)
AliasesPeroxisome Proliferator-Activated Receptor
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionneurons, astrocytes, microglia, and oligodendrocytes, where they modulate critical processes including neuroinflammation, mit
PathwaysApoptosis, Autophagy, Differentiation, Epigenetic, Lipid Metabolism
UniProt IDSearch UniProt
GeneCardsPPAR
Human Protein AtlasPPAR
Associated DiseasesAD, Als, Alzheimer, AMI, ARDS
Known Drugs/Compoundskaempferol, SDHHQ
InteractionsABCA1, ABCA7, ABCB1, ACSL4, Actin, AEP
KG Connections989 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (64)

Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Membrane Cholesterol Gradient Modulators
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
...
Score: 0.68
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Microbial Inflammasome Priming Prevention
Score: 0.65
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Related Analyses (28)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (4)

TUG C-terminal fragment nuclear interactions
exploratory · proposed · Score: 0.85
Pathway analysis of aminophylline effects on neuronal signal
exploratory · proposed · Score: 0.70
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (7)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: expressed_in
ACE Gene
gene · KG edge: regulates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibits
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibits

Knowledge Graph (12 edges)

PPAR implicated_in obesity
PPAR implicated_in ARDS
PPAR implicated_in degenerative disease
PPAR implicated_in neurodegenerative disease
CLDN1 activates PPAR
PPAR activates TNF
PPAR activates OCLN
PPAR inhibits MLCK
AQP4 activates PPAR
PRKN activates PPAR

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