Contents

TNF - Tumor Necrosis Factor

🧬 Gene Info

Gene Symbol	TNF
Full Name	Tumor Necrosis Factor
Aliases	TNF-α
Chromosome	6p21.33
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	immune cells and endothelial cells](/cell-types/endothelial-cells) - Activates NF-κB and MAPK pathways - [Predominantly pro-survival sign
Molecular Weight	26 kDa
Exons	3
Pathways	NF-κB signaling, NF-κB, MAPK, PI3K
Ensembl ID	ENSG00000232890
GeneCards	TNF
Human Protein Atlas	TNF
TNFR1 (p55)	Ubiquitous, death domain
TNFR2 (p75)	Immune cells, tissue-specific
Caspase Activation	Apoptosis pathways
Associated Diseases	AD, Age-related macular degeneration, Aging, Alopecia Areata, Als
Known Drugs/Compounds	ACBA, Adalimumab, Andrographis paniculata, anti-TNF-α monoclonal antibody, BAICALEIN, berberine
Interactions	A2M, ABCA1, ABCB1, ABCG1, ABCG2, ACE
KG Connections	5961 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

TNF inhibits OCLN

TNF participates_in TNF_PATHWAY

MMP9 interacts_with TNF

TNF activates TNFR2

NCSTN interacts_with TNF

FAS activates TNF

TNF interacts_with LMNA

TNF interacts_with APH1B