protein 629 words KG: DYNEIN
Contents

Dynein — Cytoplasmic Dynein 1

🔬 Protein Info
Gene SymbolDYNEIN
Full NameDynein — Cytoplasmic Dynein 1
AliasesCytoplasmic Dynein 1
Protein TypeProtein
FunctionDynein is a large motor protein complex that transports cargo along microtubules toward the minus end, powering retrograde axonal transport from nerve terminals to cell bodies
Subcellular Localizationthe microtubule-organizing center near the cell body). The complex comprises multiple subunits with distinct functional
Molecular Weight500 kDa
PathwaysAutophagy, Pyroptosis
UniProt IDSearch UniProt
GeneCardsDYNEIN
Human Protein AtlasDYNEIN
Associated DiseasesAls, disease, Parkinson's Disease
InteractionsA2M, Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1, AMYLOID
KG Connections221 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (25)

Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.55
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
← Prevpg 2/2

Related Analyses (10)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: expressed_in
blarcamesine-axon
clinical_trial · KG edge: causes
Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with

Knowledge Graph (12 edges)

DYNEIN causes PAFAH1B1
DYNEIN causes DAB1
DYNEIN causes REELIN
CDK5 causes DYNEIN
LIS1 interacts_with DYNEIN
DCX causes DYNEIN
MAPT associated_with DYNEIN
A2M interacts_with DYNEIN
APOE interacts_with DYNEIN
PSEN2 interacts_with DYNEIN

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