protein 629 words KG: DYNEIN
Contents

Dynein — Cytoplasmic Dynein 1

🔬 Protein Info
Gene SymbolDYNEIN
Full NameDynein — Cytoplasmic Dynein 1
AliasesCytoplasmic Dynein 1
Protein TypeProtein
FunctionDynein is a large motor protein complex that transports cargo along microtubules toward the minus end, powering retrograde axonal transport from nerve terminals to cell bodies
Subcellular Localizationthe microtubule-organizing center near the cell body). The complex comprises multiple subunits with distinct functional
Molecular Weight500 kDa
PathwaysAutophagy, Pyroptosis
UniProt IDSearch UniProt
GeneCardsDYNEIN
Human Protein AtlasDYNEIN
Associated DiseasesAls, disease, Parkinson's Disease
InteractionsA2M, Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1, AMYLOID
KG Connections221 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (25)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Glial Glycocalyx Remodeling Therapy
Score: 0.65
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Related Analyses (10)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: expressed_in
blarcamesine-axon
clinical_trial · KG edge: causes
Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with

Knowledge Graph (12 edges)

DYNEIN causes PAFAH1B1
DYNEIN causes DAB1
DYNEIN causes REELIN
CDK5 causes DYNEIN
LIS1 interacts_with DYNEIN
DCX causes DYNEIN
MAPT associated_with DYNEIN
A2M interacts_with DYNEIN
APOE interacts_with DYNEIN
PSEN2 interacts_with DYNEIN

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