protein 1,419 words KG: BECLIN1
Contents

Beclin-1

🔬 Protein Info
Gene SymbolBECLIN1
Full NameBECN1
Chromosome17q21
Protein TypeGene
Functionis a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis
PathwaysApoptosis, Autophagy, Mtor, Oxidative Stress
GeneCardsBECLIN1
Human Protein AtlasBECLIN1
Associated DiseasesAls, Alzheimer, Cancer, Colorectal Cancer, Glioblastoma, Inflammation
InteractionsABCA1, ACTB, ADSL, AKT, AKT1, ALZHEIMER
KG Connections618 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (22)

APOE-Dependent Autophagy Restoration
Score: 0.89
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
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Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (3)

CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
ACTB Gene
gene · KG edge: activates
AKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CHOP regulates BECLIN1
FIS1 associated_with BECLIN1
VEGF associated_with BECLIN1
BAX associated_with BECLIN1
TRAF6 associated_with BECLIN1
CHOP associated_with BECLIN1
NRF2 associated_with BECLIN1
MTOR associated_with BECLIN1
BECLIN1 associated_with BCL2
BECLIN1 associated_with TAAR1

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