protein 2,518 words KG: ANG
Contents

ANG Protein

🔬 Protein Info
Gene SymbolANG
AliasesGene profile: ANG, Angiogenin
Chromosome14q11.2
Protein TypeProtein
Functionis a multifunctional protein that plays critical roles in both physiological and pathological processes within the nervous system.
Molecular Weight14 kDa
Amino Acids147 aa
Exons2
PathwaysNF-κB
UniProt IDSearch UniProt
GeneCardsANG
Human Protein AtlasANG
Associated DiseasesCardiac, Heart Failure, Hypertension, Inflammation, Neuroinflammation
InteractionsActin, AGING, AKT, ANXA2, APOE, APOPTOSIS
KG Connections263 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (36)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Membrane Cholesterol Gradient Modulators
Score: 0.71
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Flotillin-1 Stabilization Compounds
Score: 0.68
...
Score: 0.68
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
APOE-Dependent Autophagy Restoration
Score: 0.89
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
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Related Analyses (9)

Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: expressed_in
ACE Gene
gene · KG edge: implicated_in
ANXA2 — Annexin A2
gene · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

PKC inhibits ANG
ANG activates KCNK2
ANG inhibits KCNK2
ANG activates NRP1
ANG associated_with APOE
ANG protects_against SLC44A2
TRPA1 regulates ANG
CAT activates ANG
ANG activates PIEZO1
ANG activates PIEZO2

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