protein

PKR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PKR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

25Outgoing

15Incoming

0Experiments

0Debates

Summary

PKR (EIF2AK2) is a 98 kDa serine/threonine kinase that plays critical roles in the integrated stress response, translational control, and neuroinflammation, with key implications for Alzheimer's disease, Parkinson's disease, and ALS

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	PKR
Aliases	EIF2AK2, Protein Kinase R
Function	In the context of neurodegenerative disorders, PKR has emerged as a key player in the pathogenesis of Alzheimer's disease, Parkinson's disease, and other conditions.
Subcellular Localization	neurodegenerative diseases
Molecular Weight	98 kDa
Pathways	Integrated Stress Response
GeneCards	PKR
Human Protein Atlas	PKR
Associated Diseases	ALS, Alzheimer's Disease, Tau Hyperphosphorylation
Known Drugs/Compounds	Aβ(1-42), tunicamycin
Interactions	CD8, EIF2AK2, EIF2S1, G3BP1, GCN2, GSK-3Β
KG Connections	40 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PKR["PKR"]
    Integrated_Stress_Response["Integrated Stress Response"]
    PKR -->|"activates"| Integrated_Stress_Response
    CANCER["CANCER"]
    CANCER -->|"regulates"| PKR
    CLUSTERIN["CLUSTERIN"]
    CLUSTERIN -->|"co_discussed"| PKR
    style PKR fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7

Outgoing (25)

Target	Relation	Type	Str
TAU	phosphorylates	protein	0.95
Integrated Stress Response	activates	pathway	0.95
Tau Hyperphosphorylation	causes	phenotype	0.90
GSK-3Β	activates	gene	0.90
tau phosphorylation	mediates	process	0.88
MAPT	upregulates	gene	0.85
tau	modulates	protein	0.85
Alzheimer's Disease	associated_with	disease	0.85
apoptosis	associated_with	process	0.80
Chronic Traumatic Encephalopathy	contributes_to	disease	0.75
STING	activates	gene	0.70
TLR	regulates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
RNA	activates	gene	0.60
neuroinflammation	interacts_with	disease	0.60
neurons	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
TLR	activates	gene	0.60
TGF	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
RAN	regulates	gene	0.60
RNA	regulates	gene	0.60
ALS	associated_with	disease	0.60
STING	co_expressed_with	gene	0.50

Incoming (15)

Source	Relation	Type	Str
Aβ(1-42)	activates	compound	0.90
tunicamycin	activates	drug	0.90
Brain Inflammation	upregulates	process	0.85
ALZHEIMER DISEASE	associated_with	gene	0.70
IFN	regulates	gene	0.60
CD8	activates	gene	0.60
ATG	regulates	gene	0.60
EIF2AK2	activates	gene	0.60
EIF2S1	activates	gene	0.60
G3BP1	activates	gene	0.55
GCN2	activates	gene	0.55
PERK	activates	gene	0.55
CANCER	regulates	gene	0.50
CLUSTERIN	co_discussed	protein	0.50
PERK	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PKR in their description or question text

No additional research found

PKR