| Gene Symbol | PKRPROTEIN |
| Protein Type | Kinase |
| Function | is a 98 kDa serine/threonine protein kinase that plays critical roles in the cellular stress response, particularly in the integrated stress response (ISR). |
| Primary Expression | the brain, with particularly high levels in neurons and microglia, where it participates in both cell-autonomous and non-cell-autonomous pathogenic pr |
| Subcellular Localization | </strong></td><td>Cytoplasm, Nucleus</td></tr> |
| Molecular Weight | 98 kDa |
| GeneCards | PKRPROTEIN |
| Human Protein Atlas | PKRPROTEIN |
| Endoplasmic reticulum stress | Through the PERK pathway (PKR shares homology with PERK, another eIF2α kinase) |
| Oxidative stress | Via mechanisms involving reactive oxygen species |
| Pro-inflammatory cytokines | Including interferon-gamma and TNF-alpha |
| Aggregated proteins | Including amyloid-beta and alpha-synuclein |
| Cellular damage signals | Including pathogen-associated molecular patterns |
| Associated Diseases | ALS, Alzheimer's Disease, Tau Hyperphosphorylation |
| Known Drugs/Compounds | Aβ(1-42), tunicamycin |
| Interactions | CD8, EIF2AK2, EIF2S1, G3BP1, GCN2, GSK-3Β |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!