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mechanism 624 words KG: PSP
Contents

integrin-ecm-signaling-cbs-psp

⚙ Mechanism Info
NamePSP
Key Genes/Proteins4R-tau, ABCA7, Actin, AGING, AKT, ALZHEIMER
Related DiseasesAging, Als, ALS, Alzheimer, Alzheimer's disease
Related PathwaysAkt

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Wikipedia

Related Hypotheses (51)

TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78Senescence-Activated NAD+ Depletion Rescue
Score: 0.76Smartphone-Detected Motor Variability Correction
Score: 0.74Senescence-Associated Myelin Lipid Remodeling
Score: 0.73Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Adenosine-Astrocyte Metabolic Reset
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72Retinal Vascular Microcirculation Rescue
Score: 0.72Purinergic Signaling Polarization Control
Score: 0.71Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71Orexin-Microglia Modulation Therapy
Score: 0.71Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
pg 1/3Next →

Related Analyses (28)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (9)

4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omi
validation · proposed · Score: 0.40Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40

See Also (11)

Amyotrophic Lateral Sclerosis
redirect · KG edge: expressed_inFrontotemporal Dementia (FTD)
disease · KG edge: associated_withApoptosis in Neurodegeneration
entity · KG edge: associated_withAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_targetGenes
index · KG edge: activates

Knowledge Graph (12 edges)

DUSP10 associated_with PSP
MAP1S associated_with PSP
PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
TAU activates PSP

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